Selênio, atividade biológica e sua relação com o câncer: uma revisão de literatura

José Freitas da  Silva

doi:10.59171/nutrivisa-2015v2e9092

Authors

José Freitas da Silva Mestrando (aluno especial) em Nutrição e Saúde pela Universidade Estadual do Ceará. Especialista em Biotecnologia pela Faculdade Stella Maris. Graduado em Biologia pela Universidade Vale do Acaraú (UVA).

DOI:

https://doi.org/10.59171/nutrivisa-2015v2e9092

Keywords:

cancer, prevention, selenium

Abstract

Selenium is a micronutrient that is essential for human beings, involved in several metabolic functions and also linked to cancer prevention. This study aimed to show the importance of selenium to the biological activity and its relationship to cancer. The study was based on a literature review, in which several works published from 1990 to 2014 were analyzed. The research was conducted by collecting information on nutrition books and electronic databases, such as Scielo, ScienceDirect and digital libraries of higher education institutions. The results showed that selenium is an essential micronutrient for human beings, because its residual concentrations allow growth, normal development and maintenance of homeostatic functions of body; it has an antioxidant function, neutralizes free radicals; regulates the immune system; besides that, it acts in the prevention of several diseases and colon cancer, ovarian cancer, bladder cancer, breast and prostate cancer, allowing to conclude that selenium is an essential important element for biological activity in human beings and it also works as an antimutagenic agent in preventing malignant transformation of normal cells, it also indicates that can be applied for the reduction of toxic cytostatic.

References

ALAEJOS, M. S.; ROMERO, F. J. D.; ROMERO, C. D.. Selenium and cancer: some nutritional aspects. Nutrition, New York, v. 16, n. 5, p. 376-383, may, 2000.

ALLAN, C. B.; LACOURCIERE, G. M.; STADTMAN, T. C. Responsiveness of selenoproteins to dietary selenium. Annual Review of Nutrition, v. 19, p. 1–16, 1999.

ALISSA, E. M.; BAHIJRI, S. M.; FERNS, G. A. The controversy surrounding selenium and cardiovascular disease: a review of the evidence.

Medical Science Monitor, v. 9, n. 1, p. RA9-18, Jan. 2003.

ALMONDES, K. G. S. et al. The role of selenoproteins in câncer. Revista da Associação Médica Brasileira, São Paulo, v. 56, n. 4, p. 484-488, 2010.

AMAYA-FARFAN, J.; DOMENE, S. M. A.; PADOVANI, R. M. DRI: síntese comentada das novas propostas sobre recomendações nutricionais para antioxidantes. Revista de Nutrição, Campinas, v. 14, n. 1, p. 71-78, jan./abr. 2001.

BEHR, C. S. Efeito de uma dieta enriquecida com castanha-do-brasil (Bertholletia excelsa, L.) no estado nutricional relativo ao selênio de idosos não institucionalizados. 2004. 99 p. Dissertação (Mestrado em Ciências dos Alimentos) - Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, 2004.

BRATAKOS, M.S. et al. The nutritional selenium status of healthy greeks. The Science of the Total Environment, Amsterdan, v. 91, p.161-176, feb. 1990.

BRODY, T. Nutritional Biochesmistry. Califórnia: Academic Press, 1994..

BROWN, K. M.; ARTHUR, J. R. Selenium, selenoproteins and human health: a review. Public Health Nutr. v. 4, n. 2B, p. 593- 599, Apr. 2001.

COMINETTI, C. et al. Considerações sobre estresse oxidativo, selênio e nutrigenética. Nutrire: Revista da Sociedade Brasileira de Alimentação e Nutrição,São Paulo, v. 36, n. 3, p. 131-153, dez. 2011.

CUNHA, D. F.; CUNHA, S. F. C.. Microminerais. In: OLIVEIRA, J. E.D.; MARCHINI, J. S. (Org). Ciências Nutricionais. 1ª ed. São Paulo: Sarvier, 1998, p. 150.

DUNTAS, L. H. The Role of Selenium in Thyroid Autoimmunity and Cancer. Thyroid, EUA, v. 16, n. 5, p. 455-460, may. 2006.

HAMILTON, S. J. Review of selenium toxicity in the aquatic food chain. Science of the Total Environment, v. 326, p. 1–31, jan. 2004.

HARVIE, M. Nutritional Supplements and Cancer: Potential Benefits and Proven Harms. Asco Educational Book, Nutritional Supplements and Cancer, Wythenshawe, p. 478-486, 2014.

KECK, A. S.; FINLEY, J. W. Database values do not reflect selenium contents of grain, cereals, and other foods grown or purchased in the upper Midwest of the United States. Nutrition Research. Tarrytown, v. 26, n. 1, p. 17-22, jan. 2006.

LUTY-FRACKIEWICZ, A. The role of selenium in cancer and viral infection prevention. International Journal of Occupational Medicine and Environmental Health, Poland, v. 18, n. 4, p. 305–311, oct. 2005.

MANDAIR, D. et al. Prostate cancer and the influence of dietary factors and supplements: a systematic review. Nutrition & Metabolism, Reino Unido, v. 11, n. 30, p. 1-11, jun. 2014.

MURAWAKI, Y. et al. Aberrant expression of selenoproteins in the progression of colorectal cancer. Cancer Letters, Tottori, v. 259, n. 2, p. 218-230, feb. 2007.

NAVARRO-ALARCÓN, M.; LÓPES-MARTÍNEZ, M. C. Essentiality of selenium in the human body: relationship with different diseases. The Science of the Total Environment, Amsterdan, v. 249, p. 347-371, apr. 2000.

NAVARRO-ALARCON, M.; CABRERA-VIQUE, C. Selenium in food and the human body: A review. Science of the Total Environment, Granada, v. 400, n. 1-3, p. 115-141, aug. 2008.

RAYMAN; M. P. The importance of selenium to human health. The Lancet, London, v. 356, n. 9225, p. 233-241, july. 2000.

RAYMAN; M. P. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proceedings of the Nutrition Society, Ireland, v. 64, n. 4, p. 527-542, nov. 2005.

REILLY, C. Selenium in Food and Health. 2ª ed. Germany: Springer, 2006.

SANTOS, I. G.; STANCARI, P. C. S. Carências Nutricionais. In: SANTOS, I. G. (Org). Nutrição: da assistência à promoção da saúde. 1ª ed. São Paulo: RCN, 2007, p. 131.

SIEJA, K.; TALERCZYK, M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecologic Oncology, Szczecin, v. 93, n. 2, p. 320-327, may. 2004.

SILVA, C. R. Avaliação do estado nutricional relativo ao selênio de pré-escolares institucionalizados. 2006. 1-18f. Dissertação (Mestrado) – Programa de Pós-Graduação em Alimentos e Nutrição, Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos. Biblioteca Digital da UNICAMP, Campinas, 2006. Disponível em: . Acesso em: 7 mai. 2014.

SUZANA, S. et al. Relationship between selenium and breast cancer: a case-control study in the Klang Valley. Singapore Medical Journal, Malaysia, v. 50, n. 3, p. 265-269, 2009.

TABASSUM, A.; BRISTOW, R.G.; VENKATESWARAN, V. Ingestion of selenium and other antioxidants during prostate cancer radiotherapy: A good thing?. Cancer Treatment Reviews, Toronto, v. 36, n. 3, p. 230-234, may. 2010.

TINGGI U.. Essentiality and toxicity of selenium and its status in Australia: a review. Toxicol Lett, Ireland, v. 137, p. 103–110, 2003.

VIARO, R. S.; VIARO, M. S.; FLECK, J. Importância bioquímica do selênio para o organismo humano. Disciplinarum Scientia, Série: Ciências Biológicas e da Saúde, Santa Maria, v. 2, n.1, p. 17-21, 2001. Disponívelem: <http://sites.unifra.br/Portals/36/CSAUDE/2001/a_importancia.pdf>. Acesso em: 2 abr. 2014.

ZENG, H.; COMBS, G. F. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. Journal of Nutritional Biochemistry, Grand Forks, v. 19, n. 1, p. 1-7, jan.2008.