Eficácia da suplementação com probióticos no manejo da Doença Celíaca: revisão sistemática

Saraia Paulino da Silva Navarro; Yasmin Rodrigues de Camargo Sartori; Lucas Henrique Gomes Castro; Patricia Ucelli Simioni

doi:10.52521/nutrivisa.v12i1.15936

Authors

Saraia Paulino da Silva Navarro Universidade Anhembi Morumbi - UAM, Piracicaba, SP, Brasil https://orcid.org/0009-0003-8028-8525
Yasmin Rodrigues de Camargo Sartori Universidade Anhembi Morumbi - UAM, Piracicaba, SP, Brasil https://orcid.org/0009-0002-8261-4446
Lucas Henrique Gomes Castro Universidade Anhembi Morumbi - UAM, Piracicaba, SP, Brasil https://orcid.org/0009-0005-8692-2413
Patricia Ucelli Simioni Universidade Anhembi Morumbi - UAM, Piracicaba, SP, Brasil https://orcid.org/0000-0002-6951-5040

DOI:

https://doi.org/10.52521/nutrivisa.v12i1.15936

Keywords:

celiac disease; probiotics; gut microbiota; gluten-free diet; intestinal inflammation.

Abstract

Celiac disease is an autoimmune condition triggered by gluten ingestion, for which the only currently effective treatment is strict adherence to a gluten-free diet (GFD). Nevertheless, some patients continue to present gastrointestinal symptoms and intestinal dysbiosis. Gut microbiota modulation through probiotic supplementation has emerged as a promising adjunct therapeutic strategy. The aim of this study was to systematically review randomized clinical trials assessing the effects of probiotic supplementation on gastrointestinal symptoms and gut microbiota composition in patients with celiac disease. Studies published in the last ten years, in English and Portuguese, that used probiotics alone and compared them with placebo were included. Searches were conducted in Scielo, Lilacs, PubMed, Cochrane, and Medline databases, following a protocol registered in PROSPERO and PRISMA guidelines. The results indicate that strains such as Lactobacillus rhamnosus, Bifidobacterium breve, and Lactobacillus casei are associated with reduced inflammation, restoration of gut microbiota balance, and improvement of gastrointestinal symptoms. Despite methodological heterogeneity, the findings suggest that probiotics may play a relevant complementary role in the clinical management of celiac disease.

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