Yacon syrup supplementation improves cholesterol and body composition in overweight and obese women: a double-blind randomized clinical trial
DOI:
https://doi.org/10.52521/nutrivisa.v11i1.14314Palabras clave:
Smallanthus sonchifolius, Yacon, Obesity, Women, Oxidative stressResumen
Introduction: Obesity is a multifactorial chronic disease with high prevalence among women in Brazil. It can cause changes in glycemic, lipid and anthropometric profiles, bringing about adjacent diseases. Yacon syrup contains prebiotics that have been shown to have a positive effect on obesity originated diseases. Our study evaluated the effect of long-term use of yacon syrup on lipid, glycemic, anthropometric profiles and oxidative damage markers in overweight or obese women assisted in an university extension project. Materials and Methods: In this randomized, double-blind clinical trial, 15 adult women were allocated into yacon group (n=10) and control group (n=5). They consumed 12 mL of yacon syrup (5.3 g of fructooligosaccharides) and 12 mL of maltodextrin syrup (placebo) for 30 days, after breakfast, and followed an individualized food plan. Blood samples were collected and an anthropometric assessment was performed before (D1) and after (D2) the 30 days of intervention. Results and discussion : There was no significant change in fasting blood glucose in any of the evaluated groups (P<0,05). There was a decrease in the amount of body fat, cholesterol and 8-isoprostane after 30 days of yacon syrup supplementation (P<0,05). Conclusion: Chronic yacon syrup had no effect on the glycemic profile, but decreased total cholesterol, body fat and 8-isoprostane levels in overweight or obese women.
Citas
ADRIANO, L.S.; DIONÍSIO, A.P.; ABREU, F.A.P.; CARIOCA, A.A.F.; ZOCOLO, G.J.; WURLITZER, N.J.; PINTO, C.O.; OLIVEIRA, A.C.; SAMPAIO, H.A.C. Yacon syrup reduces postprandial glycemic response to breakfast: A randomized, crossover, diouble-blind clinical trial. Food Research International.;126:108682. 2019. https://doi.org/10.1016/j.foodres.2019.108682.
ASSOCIAÇÃO BRASILEIRA PARA O ESTUDO DA OBESIDADE E DA SÍNDROME METABÓLICA. Diretrizes Brasileiras de Obesidade. 4. ed. São Paulo: ABESO, 2016. https://abeso.org.br/wp-content/uploads/2019/12/Diretrizes-Download-Diretrizes-Brasileiras-de-Obesidade-2016.pdf.
CAMPOS, D.; BETALLELUZ-PALLARDEL, I.; CHIRINOS, R.; AGUILAR-GALVEZ, A.; NORATTO, G.; PEDRESCHI, R. Prebiotic effects of yacon (Smallanthus sonchifolius Poepp. & Endl), a source of fructooligosaccharides and phenolic compounds with antioxidant activity. Food Chemistry.;135(3):1592–9. 2012. http:// HIPERLhttps://doi.org/10.1016/j.foodchem.2012.05.088.
DIAS, P.C.; HENRIQUES, P.; ANJOS, L.A.; BURLANDY, L. ACadernos de Saúde Pública [Internet]. ;33(7), 2017. https://www.scielosp.org/article/csp/2017.v33n7/e00006016/pt/.
DIONÍSIO, A.P.; SILVA, M.F.G; CARIOCA, A.A.F.; ADRIANO, L.S.; ABREU, F.A.P.; WURLITZER, N.J. Effect of yacon syrup on blood lipid, glucose and metabolic endotoxemia in healthy subjects: a randomized, double-blind, placebo-controlled pilot trial. Food Science and Technology. ;40(1): 194–201. 2020. http:// https://doi.org/10.1590/fst.38218.
FALUDI, A.A.; IZAR, M.C.O.; SARAIVA, J.F.K.; CHACRA, A.P.M.; BIANCO, H.T.; AFIUNE NETO, A.; BERTOLAMI, A.; PEREIRA, A.C.; LOTTENBERG, A.M.; SPOSITO, A.C.; CHAGAS, A.C.P.; CASELLA-FILHO, A.; SIMÃO, A.F.; ALENCAR FILHO, A.C.; CARAMELLI, B.; MAGALHÃES, C.C.; MAGNONI, D.; NEGRÃO, C.E.; FERREIRA, C.E.S.; SCHERR, C.; FEIO, C.M.A.; KOVACS, C.; ARAÚJO, D.B.; CALDERARO, D.; GUALANDRO, D.M.; MELLO JUNIOR, E.P.; ALEXANDRE, E.R.G.; SATO, I.E.; MORIGUCHI, E.H.; RACHED, F.H.; SANTOS, F.C.; CESENA, F.H.Y.; FONSECA, F.A.H.; FONSECA, H.A.R; XAVIER, H.T.; PIMENTEL, I.C.; GIULIANO, I.C.B.; ISSA, J.S.; DIAMENT, J.; PESQUERO, J.B.; SANTOS, J.E.; FARIA NETO, J.R.; MELO FILHO, J.X.; KATO, J.T.; TORRES, K.P.; BERTOLAMI, M.C.; ASSAD, M.H.V.; MINAME, M.H.; SCARTEZINI, M,.; FORTI, N.A.; COELHO, O.R.; MARANHÃO, R.C.; SANTOS FILHO, R.D.; ALVES, R.J.; CASSANI, R.L.; BETTI, R.T.B.; CARVALHO, T.; MARTINEZ, T.L.R.; GIRALDEZ, V.Z.R.; SALGADO FILHO, W. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – . Arq Bras Cardiol 2017;109 (2Supl.1):1-76. 2017. https://doi.org/10.5935/abc.20170121.
FRIEDEWALD, W.T.; LAVY, R.I.; FREDRICKSON, D.S. Estimation to density lipoprotein without use of the preparative ultracentrifuge. Clinical Chemistry. ;18(6):499-502.1972. https://doi.org/10.1093/clinchem/18.6.499.
GENTA, S.B.; CABRERA, W.M.; GRAU, A.; SÁNCHEZ, S.S. Subchronic 4-month oral toxicity study of dried Smallanthus sonchifolius (yacon) roots as a diet supplement in rats. Food and Chemical Toxicology , 43, 1657–1665. 2005. https://doi.org/10.1016/j.fct.2005.05.007.
GENTA, S.; CABRERA, W.; HABIB, N.; PONS, J.; CARILLO, I.M.; GRAU, A.; SÁNCHEZ, S. Yacon syrup: Beneficial effects on obesity and insulin resistance in humans. Clinical Nutrition. ;28(2):182–7. 2009 https://doi.org/10.1016/j.clnu.2009.01.013.
GRANCIERI, M.; MACHADO, P.A.; OLIVEIRA, D.F.; MARCON, L.N.; TOSTES, M.G.V.; COSTA, N.M.B.; IGNACCHITI, M.D.C.; NUNES, L.C.; VIANA, M.L. Efeito da farinha de yacon (Smallanthus sonchifolius) na resposta imunológica intestinal no câncer colorretal. Braspen Journal.; 31(4) :35-39. 2016. http://www.braspen.com.br/home/wp-content/uploads/2017/02/10-AO-Efeito-da-farinha.pdf.
HABIB, N.C.; HONORÉ, S.M.; GENTA, S.B.; SÁNCHEZ, S.S. Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats: Biochemical approach. 15;194(1):31–9. 2011. https://doi.org/10.1016/j.cbi.2011.08.009.
HABIB, N.C.; SERRA-BARCELLONA, C.; HONORÉ, S.M.; GENTA, S.B.; SÁNCHEZ, S.S. Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats. Pharmaceutical Biology. 8;53(8):1183–93. 2015. http:// https://doi.org/10.3109/13880209.2014.970285.
HONG, S.S.; LEE, S.A.; HAN, X.H.; LEE, M.H.; HWANG, J.S.; PARK, J.S.; OH, K.W.; HAN, K.; LEE, M.K.; LEE, H.; KIM, W.; LEE, D.; HWANG, B.Y. Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production. Chemical & Pharmaceutical Bulletin. ;56(2):199–202. 2008. https://doi.org/10.1248/cpb.56.199.
JACKSON, A.S.; POLLOCK, M.L. Generalized equations for predicting body density of men. British Journal of Nutrition. ; 40(3):497-504. 1978. https://doi.org/10.1079/bjn19780152.
JANG, H.W.; GO, S.Y.; HONG M.J.; LEE, Y.H. Inhibitory Effect of Yacon Leaf Extract on the Metabolic Syndrome Induced by a High Fructose Diet in Rats. Journal of the Korean Society of Food Science and Nutrition.; 49(12):1301–8. 2020. https://doi.org/10.3746/jkfn.2020.49.12.1301.
KOK, N.; ROBERFROID, M.; ROBERT, A.; DELZENNE, N. Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats, British Journal of Nutrition. 76, 881–890. 1996. http:// https://doi.org/10.1079/bjn19960094.
MACHADO, A.M.; DA SILVA, N.B.; CHAVES, J.B.; ALFENAS, R.D. Consumption of yacon flour improves body composition and intestinal function in overweight adults: A randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition ESPEN [Internet]. ;29:22-9. 2019. https://doi.org/10.1016/j.clnesp.2018.12.082.
MACHADO, A.M.; SILVA, N.B.; FREITAS, R.M.; FREITAS, M.B.; CHAVES, J.B.; OLIVEIRA, L.L.; MARTINO, H.S.; ALFENAS, R.D. Effects of yacon flour associated with an energy restricted diet on intestinal permeability, fecal short chain fatty acids, oxidative stress and inflammation markers levels in adults with obesity or overweight: a randomized, double blind, placebo controlled clinical trial. Archives of Endocrinology and Metabolism [Internet]. 2020. https://doi.org/10.20945/2359-3997000000225.
ROCHA, D.M.U.P.; RIBEIRO, P.V.M.; CALDAS, A.P.S.; SILVA, B.P.; SILVA, A.; ALMEIDA, A.P.; SILVA, N.B.M.; MACHADO, A.M.; ALFENAS, R.C.G. Acute consumption of yacon shake did not affect glycemic response in euglycemic, normal weight, healthy adults. Journal of Functional Foods; 44:58–64. 2018. https://doi.org/10.1016/j.jff.2018.02.029.
MIKAMI, I.; YAMAGUCHI, M.; SHINMOTO, H.; TSUSHIDA, T. Development and Validation of a Microplate-based .BETA.-carotene Bleaching Assay and Comparison of Antioxidant Activity (AOA) in Several Crops Measured by .BETA.-carotene Bleaching, DPPH and ORAC Assays. Food Science and Technology Research.;15(2):171–8. 2009. https://doi.org/10.3136/FSTR.15.171.
MINISTÉRIO DA SAÚDE. Secretaria de Vigilância em Saúde. Departamento de Análise em Saúde e Vigilância de Doenças não Transmissíveis. Vigitel Brasil 2021: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico: estimativas sobre frequência e distribuição sociodemográfica de fatores de risco e proteção para doenças crônicas nas capitais dos 26 estados brasileiros e no Distrito Federal em 2022. Brasília: Ministério da Saúde, 132p. ISBN 978-85-334-2705-1. 2019.
OJANSIVU, I.; FERREIRA, C.L.; SALMINEN, S. Yacon, a new source of prebiotic oligosaccharides with a history of safe use. Trends in Food Science & Technology. ;22(1):40–6. 2011. https://doi.org/10.1016/j.tifs.2010.11.005.
OLIVEIRA, G.O.; BRAGA, C.P.; FERNANDES, A.A.H. Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius] treatment. Food and Chemical Toxicology.; 59:256–60.2013. https://doi.org/10.1016/j.fct.2013.05.050.
PETERS, S.A.E.; SINGHATEH, Y.; MACKAY, D.; HUXLEY, R.R.; WOODWARD, M. Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis. Atherosclerosis [Internet]. ;248:123–31. 2016. https://www.sciencedirect.com/science/article/pii/S0021915016300910.
SACRAMENTO, M.D.; SILVA, P.S.; TAVARES, M.I. Batata yacon: alimento funcional. Semioses [Internet] ; 11(3). 2017. https://doi.org/10.15202/1981996x.2017v11n3p43.
SATOH, H.; KUDOH, A.; HASEGAWA, K.; HIRAI, H.; WATANABE, T. Yacon supplementation reduces serum free fatty acids and tumor necrosis factor alpha concentrations in patients with type 2 diabetes. Diabetology International v. 5:165–174. 2014. https://doi.org/10.1007/s13340-013-0150-y.
SCHEID, M.M.; GENARO, P.S.; MORENO, Y.M.; PASTORE, G.M. Freeze-dried powdered yacon: effects of FOS on serum glucose, lipids and intestinal transit in the elderly. European Journal of Nutrition [Internet]. 53(7):1457-64. 2014. https://doi.org/10.1007/s00394-013-0648-x.
SILVA, M.F.G.; DIONÍSIO, A.P.; ABREU, F.A.P.; PINTO, C.O.; SILVA, L.M.A.E.; DE BRITO, E.S.; PONTES, D.F. Optimization of enzymatic treatment to produce yacon juice clarified by microfiltration with high levels of chlorogenic acid and fructooligosaccharides. Journal of Food Processing and Preservation, 42(6), 1–8. 2018. https://doi.org/10.1111/jfpp.13641.
SOUSA, S.; PINTO, J.; RODRIGUES, C.; GIÃO, M.; PEREIRA, C.; TAVARIA, F.; Malcata, F.X.; GOMES, A.; Pacheco, M.T.B. Pintado, M.; Antioxidant properties of sterilized yacon (Smallanthus sonchifolius) tuber flour. Food Chemistry. ;188:504–9. 2015. https://doi.org/10.1016/j.foodchem.2015.04.047.
WORLD HEALTH ORGANIZATION. Physical status: the use e interpretation of anthropometry. Geneva. 2005.
WORLD HEALTH ORGANIZATION. (1998) Obesity - preventing and managing the global epidemic. Geneva, 1998.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2024 Marília Magalhães Cabral, Antônio Augusto Ferreira Carioca, Gabriel Martins de Araújo Sousa, Paula Alexandre de Freitas, Jamile Carvalho Tahim, Thiago Santos Garces, Thereza Maria Magalhães Moreira; Saulo Chaves Magalhães; Andrelina Noronha Coelho de Souza, Ariclecio Cunha de Oliveira, Maria Luisa Pereira de Melo, Keciany Alves de Oliveira Oliveira
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
