The metabolic and anti-adiposity effects of oral Copaiba-oil supplementation are influenced by sex and obesity

Zoé Maria Neves de Carvalho  Guareschi; Marianela Diaz Urrutia; Beatriz Machado Daudt; Bruna S. Siqueira; Vanessa Marieli Ceglarek; Marcia Eduarda Dos Santos; Sabrina Grassiolli

doi:10.52521/nutrivisa.v12i1.14328

Authors

Zoé Maria Neves de Carvalho Guareschi Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE),Cascavel/PR, Brasil. https://orcid.org/0000-0002-3852-7073
Marianela Diaz Urrutia Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE),Cascavel/PR, Brasil. https://orcid.org/0000-0001-5047-953X
Beatriz Machado Daudt Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE),Cascavel/PR, Brasil. https://orcid.org/0000-0001-6605-5782
Bruna S. Siqueira Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE),Cascavel/PR, Brasil. https://orcid.org/0000-0002-2054-289X
Vanessa Marieli Ceglarek Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre/RS, Brasil. https://orcid.org/0000-0001-9374-8058
Marcia Eduarda Dos Santos Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE),Cascavel/PR, Brasil. https://orcid.org/0009-0003-1315-7832
Sabrina Grassiolli Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE),Cascavel/PR, Brasil. https://orcid.org/0000-0002-0538-2461

DOI:

https://doi.org/10.52521/nutrivisa.v12i1.14328

Keywords:

Oil-resin; natural compounds; antioxidant; obesity.

Abstract

Copaiba oil (CO-oil) is commonly used as a topical healing and anti-inflammatory product in Brazil. However, recent data indicate that oral ingestion of CO-oil has anti-adiposity effects. In the present study, we evaluated the effects of oral CO-oil supplementation on body weight (BW), food intake (FI), adiposity and metabolism in male and female obese and non-obese rats. Monosodium glutamate (MSG; 4g/Kg) was administered during the first week after birth to induce hypothalamic obesity; control (CON; non-obese) rats received equimolar saline. After weaning (30 days of life), MSG and CON males and females were randomly subdivided into CO-oil supplemented (0.5mL/Kg; 3 times/week/8 weeks) and non-supplemented (NS) groups (n = 10-15 rats/group). BW, FI, feed efficiency (FE) and adiposity were registered, as well as fasting glucose (GLU), triglycerides (TGL) and total cholesterol (TC) values. Insulin resistance (IR) was assessed using the triglyceride-glucose index (TyG). Integrative principal component analysis (PCA) showed that chronic CO-oil supplementation alters FI and FE in MSG-obese and non-obese male rats, without modifying adiposity or metabolism. However, CO-oil supplementation of MSG-obese females reduced adiposity, TGL and improved IR, in relation to non-obese females. Thus, our data indicate that CO-oil oral supplementation influences males and females differently, having greater anti-adiposity effects and benefits on the metabolic state of obese female rats.

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