Rutina reduz perda de tecido adiposo induzida pela doxorrubicina e melhora atividade antioxidante

Paula Alexandre de Freitas; Danielle Carvalho Fonseca Falanga; Raquel Cristina  de Sousa Lima Landim; Luís Sérgio Fonteles Duarte; Keciany Alves de Oliveira; Nilberto Robson Falcão do  Nascimento; Ariclécio Cunha de Oliveira

doi:10.59171/nutrivisa-2024v11e12545

Authors

Paula Alexandre de Freitas Universidade Estadual do Ceará https://orcid.org/0000-0003-1791-280X
Danielle Carvalho Fonseca Falanga Universidade Estadual do Ceará https://orcid.org/0000-0003-1274-9687
Raquel Cristina de Sousa Lima Landim Universidade Estadual do Ceará https://orcid.org/0000-0001-5098-4173
Luís Sérgio Fonteles Duarte Universidade Estadual do Ceará https://orcid.org/0009-0005-0016-4501
Keciany Alves de Oliveira Universidade Estadual do Ceará https://orcid.org/0000-0002-9928-3826
Nilberto Robson Falcão do Nascimento Universidade Estadual do Ceará https://orcid.org/0000-0001-6156-5927
Ariclécio Cunha de Oliveira Universidade Estadual do Ceará https://orcid.org/0000-0002-9295-8157

DOI:

https://doi.org/10.59171/nutrivisa-2024v11e12545

Keywords:

Doxorrubicin. Adipose Tissue. Rutin. Redox Imbalance.

Abstract

Doxorubicin (DX) is a chemotherapy drug that is widely used by neoplastic patients. However, it promotes deleterious side effects in non-tumor tissues, such as the adipose tissue. The mechanism of action of DX has been associated with greater production of reactive oxygen species, and therapies with antioxidant components, such as rutin, may be beneficial in reducing the adverse effects. Our work aimed at verifying the effect of rutin on adiposity and redox homeostasis of adipose tissue in mice treated with doxorubicin. Male Swiss mice were divided into three groups: control group (CT); doxorubicin (DX) group, that received intraperitoneally 2.5 mg/kg DX hydrochloride, twice a week for 2 weeks; and RT group (DX + rutin), that received, in addition to receiving to DX i.p., 10 mg/kg rutin orally, daily. Food intake and body weight were assessed weekly. Oxidative damage and activity of the antioxidant enzyme catalase were evaluated in the adipose tissue pads (subcutaneous, periepididymal and retroperitoneal). Rutin attenuated the loss of adipose tissue caused by DX, and increased catalase activity. These results demonstrate the importance of further studies to clarify the role of rutin in reducing chemotherapy-related side effects in organs relevant to the control of homeostasis.

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