Artigos Originais
SEMINAL PARAMETERS OF TRANSGENIC AND NON TRANSGENIC GOATS FOR THE HUMAN GRANULOCYTE COLONY FACTO
Published 2023-08-04
Keywords
- transgenc bucks,
- semen,
- spermatozoa,
- recombinant protein
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
SEMINAL PARAMETERS OF TRANSGENIC AND NON TRANSGENIC GOATS FOR THE HUMAN GRANULOCYTE COLONY FACTO. Ciência Animal, [S. l.], v. 29, n. 1, p. 30–36, 2023. Disponível em: https://revistas.uece.br/index.php/cienciaanimal/article/view/11055. Acesso em: 18 may. 2026.
Abstract
The goat species has become an excellent animal model aiming at the production of recombinant proteins in milk. Obtaining transgenic founder males is important, as they make it possible to increase the number of transgenic offspring by simply using artificial insemination. The objective of this work was to compare the seminal parameters of male transgenic (TG) and non-transgenic (NTG) goats for the human Granulocyte Colony Stimulating Factor (hG-CSF). For this purpose, weekly semen samples were collected from all animals through an artificial vagina. The following parameters were evaluated: volume, mass motility, sperm concentration, progressive individual motility (MIP), vigor and sperm pathologies. Statistical differences were observed only for volume and MIP, which had higher values (p<0.05) in TG animals. It was also observed, in both groups, a small percentage of spermatic pathologies (<2%), with no statistical difference (p>0.05). In conclusion, the presence of the transgene did not affect semen quality, favoring and contributing to the formation of a transgenic herd.References
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