Clinical, morphological and immunophenotypic characteristics of carcinoma in a mixed tumor in a male dog
Keywords:
Breast neoplasia, histology, immunohistochemistryAbstract
Mammary neoplasms in male dogs are considered rare due to their low incidence. A 9-year-old uncastrated
Rottweiler, presenting a well-defined and firm enlargement on palpation in the right thoracic mamary gland, was
treated in Fortaleza. After carrying out blood counts (true microcytic, hypochromic anemia and thrombocytosis),
cytology (PAF) suggestive of mastitis and deep skin scrapings suggestive of moderate fungal infection, oral and
topical treatment was performed, which did not provide any improvement, leading to surgical removal of the
nodule (T1: <3cm), histopathology revealed that it was a well-defined mixed tumor carcinoma (MTC) with free
margins. Immunohistochemistry (IHC) yielded the following results: Ki-67 20%; RP >75%; RE 51-75%; COX-2
score 3 (<10% strong intensity marking); HER-2 score 2 (>10% moderate and incomplete membrane staining),
configuring a Luminal B HER-2 negative molecular classification tumor. The tumor characteristics (T1/ MTC/
RP+/ RE+/ COX-2 low) indicate less aggressive biological behavior. Although mammary neoplasms are rare,
they should always be the differential diagnoses in male dogs that present enlargement in the mamary gland,
carrying out a complete clinicopathological investigation covering IHC whenever possible, to increase our
understanding of the biological behavior of these tumors.
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