Thermographic comparison between piroxicam and trocoxil anti inflammatory effects in canine mammary tumors
Keywords:
Mammary neoplasms, COX-2, Non steroidal anti-inflammatory drugs, ThermographyAbstract
Malignant mammary tumors are most prevalent neoplasms in bitches. Currently, it is known the influence of several factors and biological markers involved in tumors development, such as cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs appears as a promising adjuvant treatment. The aim of this study was to evaluate and to compare the effectiveness of piroxicam and Trocoxil® (mavacoxib) in reduce the peritumoral temperature. At random, it was selected 16 middle-aged bitches presenting mammary tumor according the routine of the Veterinary Hospital. On day 0, after clinical examination and thermography of both mammary chains, piroxicam was prescribed to group 1 (n=12) (0.3mg/kg, VO, SID, 10 days) and to group 2 (n=4) was prescribed Trocoxil® (2mg/kg, VO, single dose). After 10 days, the animals returned for further evaluation and the second thermography. The images were analyzed, tabulated and submitted to statistical analysis by the SigmaPlot® program in a simple t-test, considering p<0.05. The results indicated that Trocoxil® showed a better ability to reduce peritumoral temperature than piroxicam after 10 days of treatment (p=0.041), suggesting this drug with better efficiency in the adjuvant treatment of mammary neoplasms in bitches.
References
CASSALI, G.D.; JARK, P.C.; GAMBA, C.; DAMASCCENO, K.A.; ESTRELA-LIMA, A.; DE NARDI, A.B.; FERREIRA, E.; HORTA, R.S.; FIRMO, B.F.; SUEIRO, F.A.R.; RODRIGUES L.C.S.; NAKAGAKI, K.Y.R. Consensus regarding the diagnosis, prognosis and treatment of canine and feline mammary tumors - 2019. Brazilian Journal of Veterinary Pathology, v.13, n.3, p.555-574, 2020.
DE NARDI, A.B.; FERREIRA, T.M.M.R.; ASSUNÇÃO, K.A. Neoplasias Mamárias. In: DE NARDI, A.B.; DALECK, C.R. Oncologia em cães e gatos. 2ª ed., Rio de Janeiro: Roca, p.726-756, 2016.
DORÉ, M. Cyclooxygenase-2 expression in animal cancers. Veterinary Pathology, v.48, p.254-265, 2011.
HELLER, D.A.; CLIFFORD, C.A.; GOLDSCHMIDT, M.H; HOLT, D.E; SHOFER, F.S.; SMITH, A.; SORENMO. Cyclooxygenase-2 expression in associated with histologic tumor type in canine mammary carcinoma. Veterinary Pathology, v.42, p.776-780, 2005.
LAVAELLE, G.E.; CAMPOS, C.B.; BERTAGNOLLI, A.C; CASSALI, G.D. Canine Malignant Mammary Gland Neoplasms with Advanced Clinical Staging Treated with Carboplatin and Cyclooxygenase Inhibitors. InVivo, v. 26, n.3, p.375-379, 2012.
LIU, C.H.; CHANG, S.H.; NARKO, K.; TRIFAN, O.C.; WU, M.T.; SMITH, E.; HAUDENSCHILD, C.; LANE, T.F.; HLA, T. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. Journal of Biological Chemestry, v.276, p.18563–18569, 2001.
QUEIROGA, F.L.; PIRES, I.; PARENTE, M.; GREGÓRIO, H.; LOPES C. COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer. The Veterinary Journal, v.189, n.1, p.77-82, 2011.
RANG, H.P.; RITTER, J.M.; FLOWER, R.J.; HENDERSON, G. Fármacos anti-inflamatórios e imunossupressores. In: RANG, H.P.; RITTER, J.M.; FLOWER, R.J.; HENDERSON, G. Rang & Dale: Farmacologia. 8ª ed., São Paulo: Elsevier, p.754-794, 2016.
TEDARDI, M.V.; KIMURA, K.C.; MENDONÇA, P.P.; DAGLI, M.L.Z. Epidemiologia e Etiologia do Câncer. In: DE NARDI, A.B.; DALECK, C.R. Oncologia em cães e gatos. 2ª ed., Rio de Janeiro: Roca, p.1-28, 2016.
