)Perspectives of cold atmospheric plasma application in cutaneous wound healin
Keywords:
Plasma medicine, CAP, Regeneration, Wound, TreatmentAbstract
Plasma medicine has evolved in wound healing treatment, being highlighted as an excelent therapeutic possibility. As it is something relatively new, there is still a need to know some of its mechanisms of action and application. Therefore, this article aimed to make a survey of the literature on the application of cold atmospheric plasma in the treatment of skin wound healing as a way to guide the veterinarian to use this therapeutic resource. Plasma is generated by electromagnetic fields and is considered the fourth state of matter, having its action driven by gaseous substances. Its action occurs from the interaction of reactive species present in its jet, hich produces stimulating effects on angiogenesis, collagen production, adhesion factors from one cell to another, and cell migration, in addition to growth factors and important signals in this process. There are numerous reports of its effectiveness, both directly and indirectly, which increases its possibility of use. In general, a better definition of safe parameters and mode of application is needed, based mainly on the flow, intensity, positioning, and blasting time in the injured area. It is also important for the veterinarian to think about the particularities of the species treated at the moment, which points to the versatility of using this therapy in the wound clinic. Even in the face of these gaps, the parameters described in the literature appear to be safe and can be used as a reference for consolidating new studies in different species and clinical practices.
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