Diagnostic approach of metastatic cutaneous mastocytoma in dog

Authors

  • Letícia Almeida CAVALCANTE Faculdade de Veterinária da Universidade Estadual do Ceará
  • Amanda de Carvalho GURGEL Faculdade de Veterinária da Universidade Estadual do Ceará
  • Francisco Wesley da Silva ALVES Faculdade de Veterinária da Universidade Estadual do Ceará
  • Carla Régia Soares BEZERRA Faculdade de Veterinária da Universidade Estadual do Ceará
  • Michelle Costa e SILVA Faculdade de Veterinária da Universidade Estadual do Ceará
  • Breno Queiroz PINHEIRO Faculdade de Veterinária da Universidade Estadual do Ceará
  • Jefferson da Silva FERREIRA Faculdade de Veterinária da Universidade Estadual do Ceará
  • Isaac Neto Goes da SILVA Faculdade de Veterinária da Universidade Estadual do Ceará

Keywords:

Mast cell tumor, Neoplasm, Cytology

Abstract

Mast cell tumors are one of the most common skin neoplasms that affect dogs. The diagnosis is based on clinical and laboratory aspects, with cytology and histopathology being the preferred methods. Therefore, this study aims to report the importance of the broad diagnostic approach of metastatic cutaneous mastocytoma in a castrated a female dog attended at the Veterinary Hospital of the State University of Ceará, with a neoformation in a member compatible with mast cell tumor. The patient’s staging was performed through laboratory tests of complete blood count, aspiration cytology of regional lymph nodes and bone marrow, which showed the presence of focus of metastasis, as well as the abdominal ultrasound examination, which showed changes in the liver parenchymas and right medial iliac lymphadenopathy. Given the suspicions, the patient was euthanized and the body was sent for necropsy and histopathological examination, which confirmed the diagnosis of high-grade cutaneous mast cell tumor, with metastasis in the liver, lung, bone marrow, and lymph nodes. Thus, it can be is concluded that mast cell tumor is a neoplasm of multifactorial diagnosis, where hematological tests associated with cytology, histopathological, and imaging analyses are essential to establish the definitive diagnosis to determine a better therapeutic behavior and prognosis of canine patients.

References

ARENDT, M.L.; MELIN, M.; TONOMURA, N.; KOLTOOKIAN, M.; COURTAY-CAHEN, C.; FLINDALL, N.; BASS, J.; BOERKAMP, K.; MEGQUIR, K.; YOUELL, L.; MURPHY, S.; MCCARTHY, C.; LONDON, C.; RUTTEMAN, G.R.; STARKEY, M.; LINDBLAD-TOH, K. Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours. PLoS Genetics, v.20, n.11, p.1-21, 2015.

BERGMAN, P.J. Paraneoplastic syndromes. In: WITHROW, S.J.; MACEWEN, E.G. Small Animal Clinical Oncology. 4ª ed., WB Saunders Company; cap.5, p.83-85, 2007.

BLACKWOOD, L; MURPHY, S; BURACCO, P; DE VOS, J.P; DE FORNEL-THIBAUD, P.; HIRSCHBERGER, J.; KESSLER, M.; PASTOR, J.; PONCE, F.; SAVARY-BATAILLE, K.; ARGYLE, D.J. European consensus document on mast cell tumours in dogs and cats. Veterinary and Comparative Oncology, v.10, n.3, p.1-29, 2012.

CAIXETA, M.L.D.; SOUZA, M.A.; WANDERLEY, B.A. Alterações no hemograma de cadelas diagnosticadas com neoplasias mamárias atendidas no Centro Clínico Veterinário do UNIPAM. Research, Society and Development, v.11, n.1, p.87-92, 2022.

CAMUS, M.S.; PRIEST, H.L.; KOEHLER, J.W.; DRISKELL, E.A.; RAKICH, P.M.; ILHA, M.R.; KRIMER, P.M. Cytologic criteria for mast cell tumor grading in dogs with evaluation of clinical outcome. Veterinary Pathology, v.53, n.6, p.1-7, 2016.

DENICOLA, D.B. Células redondas In: COWELL, R.L.; TYLER, R.D.; MEINKOTH, J.H.; DENICOLA, D.B. Diagnóstico citológico e hematologia de cães e gatos. 3ª ed., Elsevier Health Sciences, cap.4, p.68-72, 2014.

KIUPEL, M.; CAMUS, M. Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors. In Veterinary Clinics of North America. Small Animal Practice, v.49, n.5, p.819-836, 2019.

KIUPEL, M.; WEBSTER, J.D.; BAILEY, K.L.; BEST, S.; DELAY, J.; DETRISAC, C.J.; FITZGERALD, S.D.; GAMBLE, D.; GINN, P.E.; GOLDSCHMIDT, M.H.; HENDRICK, M.J.; HOWERTH, E.W.; JANOVITZ, E.B.; LANGOHR, I.; LENZ, S.D.; LIPSCOMB, T.P.; MILLER, M.A.; MISDORP, W.; MOROFF, S.; MILLER, R. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Veterinary Pathology, v.48, n.1, p.147-155, 2011.

LONDON, C.A.; THAMM, D.H. Mast Cell Tumors. In: WITHROW, S.J.; VAIL, D.M.; OFRI, R. Small Animal Clinical Oncology. 5ª ed., Elsevier Health Sciences, cap.21, p.382-403, 2012.

NARDI, A.B.; HORT, R.S.; ALVES, A.E.F.; PAIVA, F.N.; LINHARES, L.C.M.; FIRMO, B.F.; SUEIRO, F.A.R.; OLIVEIRA, K.D.; LOURENÇO, S.V.; STREFEZZI, R.F.; BRUNNER, C.H.M.; RANGEL, M.M.M.; JARK, P.C.; CASTRO, J.L.C.; UBUKATA, R.; BATSCHINSKI, K.; SOBRAL, R.A.; CRUZ, N.O.; NISHIYA, A.T.; FERNNDES, S.C.; CUNHA, S.C.S.; GERARDI, D.G.; CHALLOUB, G.S.G.; BIONDI, L.R.; AMORIM, R.L.; PAES, P.R.O.; LAVALLE, G.E.; HUPPES, R.R.; GRANDI, F.; VASCONCELOS, C.H.C.; ANJOS, D.S.; LUZO, A.C.M.; MATERA, J.M.; VOZDOVA, M.; DAGLI, M.L.Z. Diagnóstico, Prognóstico e Tratamento de Tumores de Mastócitos Cutâneos e Subcutâneos Caninos. Cells, v.11, n.618, p.1-37, 2022.

PATNAIK, A.K.; EHLER, W.J.; MACEWEN, E.G. Canine Cutaneous Mast Cell Tumor: Morphologic Grading and Survival Time in 83 Dogs. Veterinary Pathology, v.21, n.5, p.469-474, 1984.

POHLMAN, L.M. Basophils, Mast Cells, and Their Disorders In: WEISS, D.J.; WARDROP, K.J. Schalm´s Veterinary Hematology. 6ª ed., Iowa: Blackwell, cap.44, p.290-297 ,2010.

SLEDGE, D.G.; WEBSTER, J.; KIUPEL, M. Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis, and treatment selection. Veterinary Journal, v.215, n.1, p.43-54, 2016.

SOUZA, A.C.F.; PASCOLI, A.L.; FERREIRA, M.G.P.A.; FILHO, N.P.R.; SILVA, I.C.R.; SANTOS, R.R.; FARO, A.M.; NARDI, A.B. Mastocitoma cutâneo canino: estudo retrospectivo dos casos atendidos pelo Serviço de Oncologia do Hospital Veterinário da FCAV-Unesp, Campus Jaboticabal, de 2005 a 2015. Pesquisa Veterinária Brasileira, v.38, n.9, p.1808-1817, 2018.

THRALL, M. Anemia não regenerativa In: THRALL, M. Hematologia e Bioquímica Clínica Veterinária. 2ª ed., Roca: São Paulo, cap.7, p.180-190, 2015a.

THRALL, M. Doenças linfoproliferativas e neoplasias mielóides In: THRALL, M. Hematologia e Bioquímica Clínica Veterinária. 2ª ed., Roca: São Paulo, cap.14, p.359-398, 2015b.

WELLE, M.M.; BLEY, C.R.; HOWARD, J.; RÜFENACHT, S. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Veterinary Dermatology. v.19, n.6, p.321-339, 2008.

Published

2022-11-17

How to Cite

CAVALCANTE, L. A. .; GURGEL, A. de C. .; ALVES, F. W. da S. .; BEZERRA, C. R. S. .; SILVA, M. C. e .; PINHEIRO, B. Q. .; FERREIRA, J. da S. .; SILVA, I. N. G. da . Diagnostic approach of metastatic cutaneous mastocytoma in dog. Ciência Animal, [S. l.], v. 32, n. 2, p. 200–208, 2022. Disponível em: https://revistas.uece.br/index.php/cienciaanimal/article/view/9493. Acesso em: 21 nov. 2024.

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