Evaluation of muscle strength and resistance of mice after protocol of atrophy due disuse
Keywords:
Murine, Functionality, Biped, QuadrupedAbstract
Reduction in muscle mass and function resulting from prolonged inactivity characterize disuse atrophy. Due to the anatomical and physiological proximity between mice and humans, experimental studies with this animal model have been carried out to understand disuse atrophy. However, there are functional specificities between the two species, given the quadrupedal and bipedal gaits. Thus, this study aimed to evaluate the physical capacity of mice after a protocol of atrophy by disuse by immobilization of the hind limbs. 12 Swiss albino mice were divided into 2 groups: control and atrophy. After 14 days of immobilization, 2 evaluation methods were proposed: maximum voluntary carrying capacity (MVCC) and forced swimming, in addition to body mass assessment. There was no significant difference between body weight and MVCC, while the swimming time of the control group was 10-fold longer compared to the atrophy group (p <0.05). Thus, it is concluded that the skeletal muscles of mice after disuse present a reduction in functional capacity; however, some evaluation methods are more sensitive to these changes than others
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