INHIBITORY EFFECT OF LINALOOL IN PREPARATIONS OF ISOLATED SMOOTH MUSCLE OF RAT TRACHEA WITH EPITHELIUM STIMULATED BY ELECTROMECHANICAL COUPLING
Keywords:
Monoterpene, smooth muscle, tracheaAbstract
Plants have been used as source of therapeutic elements employed to treat several disorders, such as hypertension and asthma. The discovery of pharmacological agents that act on the contractility of airways smooth muscle can be considered to help in treating diseases of the respiratory tract. In this study, we evaluated the effect of linalool, a terpenic constituent of various aromatic and medicinal plants as an antispasmodic agent in preparations of isolated rat trachea. Linalool fully reversed the electromechanical induced contraction in isolated preparations with (188.46±13.05 µM) and without (135.21±12.76 µM) epithelium. A lower inhibitory potency was observed in phamaco mechanical contractions induced in tracheal rings with preserved epithelium (261.34±38.22 µM) or not (593.45±11.32 µM). Linalool (100 µM and 1000 µM) was able to inhibit the curves of controlled influx for calcium and barium. In the present study, the inhibitory effect of linalool on pre-contracted rat tracheal rings was more effective in electromechanical conditions, suggesting a possible effect of this monoterpene on calcium influx through voltage-dependent channels.
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