AÇÕES ANTI - INFLAMATÓRIA E ANTINOCICEPTIVA DO EXTRATO ETANÓLICO DE Hymenaea courbaril L. EM ROEDORES

Autores

  • Fernando Cesar Rodrigues Brito Universidade Estadual do Ceará
  • Luana Mara Silva De Castro Pacheco da Cunha Universidade Estadual do Ceará
  • Danilo Oliveira Gonçalves Universidade Federal do Ceará
  • Tiago Moreira Olinda Universidade Federal do Ceará

Palavras-chave:

Hymenaea courbaril, Antinociceptivo, Carragenina, Inflamação, Jatobá, TNF-a

Resumo

The anti-inflammatory and antinociceptive actions of the Ethanolic Extract from Hymenaea courbaril L. (EEHC) were evaluated for the first time in animal models. The extract was produced using the stem bark. The preparation was administered to rodents per orally. EEHC has efficiently reduced the abdominal contortions induced by acetic acid; time of paw licking in formalin test; paw edema induced by carrageenan and dextran; leukocyte migration after intraperitoneal injection of carrageenan and myeloperoxidase expression on peritoneal exudate. EECH also improved the histopathological damage in the rat paw after carrageenan inflammation as well as reduced TNF-a expression in the scabies tissue. Doses ranging from 1 to 400 mg/kg were tested. The dose of 100 mg/kg presented significant results in ali experiments (p < 0.05). The data suggests intense anti-inflammatory and antinociceptive effects associated to extract from Hymenaea courbaril. Further studies must be carried out to elucidate the mechanisms involved.

Referências

preliminary in vivo evaluation of its antipsoriatic effect. lnt J Pharm in press, 2012.

IMAMURA, P.M.; MIRANDA, P.C.; GIACOM INI,

R.A. A complete 1H and 13C NMR data assignment for the diterpene methyl (-)­ zanzibarate by 20 spectroscopy and NOE experiments. Magn Reson Chem. v.42(6) , p.561- 3, 2004.

LIMA-NISH IMURA, N.; QUO IRIN, M.; NADDAF,

Y.G.; W ILHELM, H.M.; RIBAS, L.L.; SIERAKOWSK I, M.R. A xyloglucan from seeds of the native Brazilian species Hymenaea courbaril for micropropagation of Marubakaido and Jonagored apples . Plant Cel/ Rep. v.21(5), p.402-7 , 2003 .

MAO, H.; WEN , F.Q.; LIU, C.T.; LIANG ,

Z.A.; WANG, Z.L.; Y IN, K.S. Effect of interleukin- 5 receptor-alpha short hairpin RNA-expressing vector on bane marrow eosinophilopoiesis in asthmatic mice. Adv Ther. 23(6): 938-56 , 2006 . MATOS, F.J.A. "Hymenaea courbarif ', in "Plantas Medicinais no Brasil". (Plantarum, ed.), Fortaleza , pp. 87-91 , 2002 .

MELO, M.G.D.; ARAUJO , A.A.S.; ROCHA,,

C.P.L.; ALMEIDA, E.M.S.A.; SIQUEIRA, R.S.; BONJARDIM, L.R.; QUINTANS-JÚN IOR, L.J.

Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents. Bio/ . Pharm. Buli. v.31 , p.1977-1980, 2008 .

NOGUEIRA, R.T.; SHEPHERD ,

G.J.; LAVERDE, A.; MARSAIOLI,

A.J.; IMAMURA, P.M. Clerodane-type diterpenes from the seed pods of Hymenaea courbaril var. stilbocarpa. Phytochem . v.58(8), p.1153-7.

OLIVEIRA, R.R.B.; GÓIS, R.M.O.; SIQUEIRA, R.S.; ALME IDA, J. R. G. S.; LIMA, J. T.; NUNES,

X .P.; OLIVEIRA, V. R.; SIQUEIRA, J.S.;

QUINTANS-JÚNIOR, L.J. Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C . Sm., Fabaceae, in rodents . Braz. J. Pharmacognosy v.19(3), p.672-676 , 2009 .

OZES, O.N.; MAYO, L.D.; GUSTIN, J.A.; PFEFFER , S.R.; PFEFFER , L.M.; DONNER,

D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature v.401 , p.82-85, 1999.

SALVEMINI, D.; WANG , Z.Q.; WYATT , P.S.; BOURDON, D.M.; MARINO, M.H.; MANNING,

P.T.; CURRIE, M.G. Nitric oxide: a key mediator in the early and late phase of carrageenan­ induced rat paw inflammation . Br J Pharmaco/ . v.118(4), p.829-38 1996.

SASAK I, K.; MATSUKURA, Y.; SHIJ IMA, K.,

MIYAKE, M.; FUJIWARA , D.; KONISHI, Y . High­

performance liquid chromatographic purification of oligomeric procyanidins , trimers up to nonamers , derived from the bark of Jatoba ( Hymenaea courbari . Biosci Biotechnol Biochem v.73(6) , p.1274-9, 2009.

SAUTEB IN, L.; IALENT I, A.; IANARO , A.; OI

ROSA, M. Endogenous nitric oxide increases prostaglandin biosynthes is in carrageen in rat paw oedema . Eur J Pharmaco/. v.286(2) , p.219- 22 , 1995.

SCOGNAM ILLO-SZABÓ, M.V.R.; BECHARA,

G.H.; CUNHA, F.Q. Effect of acupunctu re on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats. Ciência Rural v .35(1), p.103- 108, 2005.

SHIBATA, M.; OHKUBO , T.; TAKAHASH I, H.;

INOKI, R. Modified formalin test: characteristic biphasic pain response. Pain v.38(3) , p.347-52 , 1989.

STEVENS , J.F.; MIRANDA, C.L.; WOLTHERS,, K.R.; SCHIMERLIK ,, M.; DEINZER, M.L.;

BUHLER , D.R. ldentification and in vitro biological activities of hop proanthocyanidins : inhibition of nNOS activity and scavenging of reactive nitrogen species . J Agric Food Chem. v.50(12) , p.3435-43 , 2002.

TAKAHATA , Y.; OHNISHl-KAMEYAMA , M.;

FURUTA, S.; TAKAHASH I, M.; SUDA, 1. Highly

polymerized procyanidins in brown soybean seed coat with a high radical-scavenging activity . J Agric Food Chem. v.49(12) , p.5843-7 , 2001 .

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Publicado

2024-09-26

Como Citar

BRITO, F. C. R.; CUNHA, L. M. S. D. C. P. da; GONÇALVES, D. O.; OLINDA, T. M. AÇÕES ANTI - INFLAMATÓRIA E ANTINOCICEPTIVA DO EXTRATO ETANÓLICO DE Hymenaea courbaril L. EM ROEDORES. Ciência Animal, [S. l.], v. 25, n. 3, p. 04–14, 2024. Disponível em: https://revistas.uece.br/index.php/cienciaanimal/article/view/13876. Acesso em: 15 out. 2024.

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Resumo Expandido - Artigos Originais