(EDEMATOGENIC ANO ANTINOCICEPTIVE ACTIVITIES OF THE LECTIN ISOLATED FROM THE ALBUMIN FRACTION OF Acacia farnesiana)
Parole chiave:
Acacia farnesiana, lectin, inflammation, nociceptionAbstract
This study aims to evaluate the activity of AFAL in the models of paw edema and chemical nociception. AFAL was injected s.c. or i.v before s.c. injection of carrageenan or dextran in rats to evaluate its pro- or anti-edematogenic effect. The antinociceptive activity was investigated by AFAL i.v. administration in mice in the writhing and formalin tests. Results were expressed as Mean ± SEM and considered significant for p <0.05 (ANOVA). AFAL (0.1 and 1 mg/kg; s.c.) induced paw edema in 30 min, remained constant until the 3rd h, increasing paw volume by 2.9x and 3.4x, respectively, compareci to saline. However, the lectin did not change the edema induced by carrageenan, dextran or formalin. AFAL reduced the number of writhes by 53% (0.1 mg/kg) 60% (1 mg/kg) and 74% (10 mg/kg), but had no effect at any phases of the formalin test. ln conclusion, AFAL presents pro-inflammatory and antinociceptive activity.
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