MORFOFISIOLOGIA DO APARELHO REPRODUTOR MASCULINO DE GATOS DOMÉSTICOS
Parole chiave:
Anatomia, biotecnologias reprodutivas, Fisiologia, Patologias, Trato urogenitalAbstract
Os gatos são considerados, cada vez mais, a primeira escolha entre os animais domésticos e se destacam como pacientes na clínica médica veterinária, em virtude de distúrbios no trato urogenital. Assim, o estudo da anatomia e fisiologia reprodutiva desses indivíduos é a base para a compreensão e intervenção sobre patologias reprodutivas e urinárias, bem como para a investigação de técnicas de reprodução. O sistema reprodutor de gatos domésticos, apesar de formado também pelos testículos, epidídimos, ductos deferentes, glândulas sexuais acessórias, uretra, pênis, sacos escrotais e prepúcio, possui diversas peculiaridades que merecem destaque. Suas funções são controladas pelos sistemas nervoso e endócrino, em uma complexa interação. Com base no exposto, este trabalho teve como objetivo desenvolver uma revisão de literatura sobre o sistema reprodutor do gato doméstico, destacando as suas particularidades, a fim de orientar os médicos veterinários quanto às principais características anatomo-fisiológicas da espécie, o que permeia a base para a sua adequada intervenção clínica, cirúrgica ou mesmo biotecnológica.
Riferimenti bibliografici
ABÉ, K.; ETO, K.; ABÉ, S. Epidermal growth factor mediates spermatogonial proliferation in newt testis. Reproductive Biology and Endocrinology, v.6, n.7, p.1-13, 2008.
ABOOD, D.Ab.; DAWOOD, M.S.; MOHAMMED, L.E. Histological Features of the Accessory Sex Gland of Indigenous Tom cat (Felis catus). Al-Anbar Journal of Veterinary Sciences, v.12, n.2, p.1-8, 2019.
ACKERMANN, C.L.; LOPES, M.D. Training tom cats for semen collection using an artificial vagina: a retrospective study. Journal of Feline Medicine and Surgery, v.22, n.12, p.1155-1159, 2020.
ALEXANDRE-PIRES, G.; MATEUS, L.; MARTINS, C.; FERREIRA-DIAS, G. Seasonal Changes in Testes Vascularisation in the Domestic Cat (Felis domesticus): Evaluation of Microvasculature, Angiogenic Activity, and Endothelial Cell Expression. Anatomy Research International, v.2012, n.583798, p.1-10, 2012.
AMELKINA, O.; SILVA, A.M.; SILVA, A.R.; COMIZZOLI, P. Transcriptome dynamics in developing testes of domestic cats and impact of age on tissue resilience to cryopreservation. BMC Genomics, v.22, n.847, p.1-15, 2021.
AXNÉR, E. Sperm maturation in the domestic cat. Theriogenology, v.66, n.1, p.14-24, 2006.
BANKS, W.J. Histologia Veterinária Aplicada. 2. ed. São Paulo: Manole, 1992.
BASHAWAT, M.; BRAUN, B.C.; MÜLLER, K.; HERMANN, B.P. Molecular phenotyping of domestic cat (Felis catus) testicular cells across postnatal development – A model for wild felids. Theriogenology Wild, v.2, n.100031, p.1-11, 2023.
BEESTON, D.; HUMM, K.; CHURCH, D.; BRODBELT, D.; O’NEILL, D.G. Occurrence and clinical management of urethral obstruction in male cats under primary veterinary care in the United Kingdom in 2016. Journal of Veterinary Internal Medicine, v.36, n.2, p.599-608, 2022.
BLOTTNER, S.; JEWGENOW, K. Moderate seasonality in testis function of domestic cat. Reproduction in Domestic Animal, v.42, n.5, p.536-540, 2007.
BORGES, N.C.S.; SAMPAIO, M.A.P.; PEREIRA, V.A.; FIGUEIREDO, M.A.; CHAGAS, M.A. Effects of castration on penile extracellular matrix morphology in domestic cats. Journal of Feline Medicine and Surgery, v.19, n.12, p.161-166, 2017.
BRITO, M.B.; MARONEZI, M.C.; USCATEGUI, R.A.R; AVANTE, M.L.; SIMÕES, A.R.; MONTEIRO, F.O.B.; FELICIANO, M.A.R. Ultrasonographic methods for evaluation of testicles in cats. Revista MVZ Córdoba, v.23, n.3, p.6888-6899, 2018.
CAI, H.; QIN, D.; PENG, S. Responses and coping methods of different testicular cell types to heat stress: overview and perspectives. Bioscience Reports, v.41, n.6, p.1-12, 2021.
CAO, Y.; LUO, G.; LUO, L.; YANG, X.; HU, J.; SHI, H.; HUANG, P.; SUN, Z.; XIA, S. Re-epithelialization resulted from prostate basal cells in canine prostatic urethra may represent the ideal healing method after two-micron laser resection of the prostate. Asian Journal of Andrology, v.17, n.5, p.831-838, 2015.
CARREAU, S.; HESS, R.A. Oestrogens and spermatogenesis. Philosophical Transactions of the Royal Society B, v.365, n.1546, p.1517-1535, 2010.
CEREGATTI, G.; FEITOSA, W.B. Male reproductive physiology of neotropical felids. Theriogenology Wild, v.1, p.1-11, 2023.
CHAUDHARY, J; HAMRA, F.K. Discovering in vitro spermatogenesis stimulating factors. Cell Death and Disease, v.6, n.e1937, p.1-2, 2015.
DAVIDSON, A.P.; BAKER, T.W. Reproductive ultrasound of the dog and tom. Topics in Companion Animal Medicine, v.24, n.2, p.64-70, 2009.
DEAN, R.C.; LUE, T.F. Physiology of penile erection and pathophysiology of erectile dysfunction. Urologic Clinics of North America, v.32, n.4, p.379-395, 2005.
DIAGONE, K.V.; FELICIANO, M.A.R.; PACHECO, M.R.; VICENTE, W.R.R. Histology and morphometry of the testes of adult domestic cats (Felis catus). Journal of Feline Medicine and Surgery, v.14, n.2, p.124-130, 2011.
DOMINGOS, T.C.S.; SALOMÃO, M.C. Meios de diagnóstico das principais afecções testiculares em cães: revisão de literatura. Revista Brasileira de Reprodução Animal, v.35, n.4, p.393-399, 2011.
DRISCOLL, C.A.; MENOTTI-RAYMOND, M.; ROCA, A.L. The near eastern origin of cat domestication. Science, v.317, n.5837, p.519-523, 2007.
DU, L., CHEN, W; CHENG, Z.; WU, S.; HE, J.; HAN, L.; HE, Z.; QIN, W. Novel gene regulation in normal and abnormal spermatogenesis. Cells, v.10, n.666, p.1-16, 2021.
DYCE, K.M.; SACK, W.O.; WENSING, C.J.G. Tratado de Anatomia Veterinária. 5. ed. Rio de Janeiro: Elsevier, 2019.
ENGLAND, G.C.W.; VON HEIMENDAHL A. BSAVA Manual of canine and feline reproduction and neonatology. 2. ed. Gloucester: British Small Animal Veterinary Association, 2011.
FARACO, C.B.; SOARES, G.M. Fundamentos do comportamento Canino e Felino. 1. ed. São Paulo: Editora Medvet, 2013.
FERRÉ-DOLCET, L.; ROMAGNOLI, S. Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility. Journal of Feline Medicine and Surgery, v.25, n.5, p.1-8, 2023.
FERREIRA, G.S.; CARVALHO, M.B.; AVANTE, M.L. Características epidemiológicas, clínicas e laboratoriais de gatos com sinais de doença do trato urinário inferior. Archives of Veterinary Science, v.19, n.4, p.42-50, 2014.
FOSTER, R.A. Male Genital Sistem. 6. ed. v.3, St. Loues: Elsevier, 2016.
FRANÇA, L.R.; GODINHO, C.L. Testis morphometry, seminiferous epithelium cycle lenght and daily sperm production in domestic cats (Felis catus). Biology of Reproduction, v.68, n.5, p.554-1561, 2003.
FREITAS, L.I.; MACHADO, R.S. Biotécnicas reprodutivas: captura, exame andrológico, conservação do ejaculado e inseminação artificial em canídeos e felídeos selvagens em risco de extinção. Veterinária e Zootecnia, v.28, p.1-9, 2021.
GAUTAM, M.; BHATTACHARYA, I.; RAI, U.; MAJUMDAR, S.S. Hormone induced differential transcriptome analysis of Sertoli cells during postnatal maturation of rat testes. Plos One, v.13, n.1, p.1-25, 2018.
GENTRY, A.S.; CLUTTON-BROCK, J.; GROVES, C.P. The naming of wild animal species and their domestic derivatives. Journal of Archaeological Science, v.31, n.5, p.645-651, 2004.
GOMES, D.O.; VIDAL, R.R.; FOEPPEL, B.F.; FARIA, D.F.; SAITO, M. Cold weather is a predisposing factor for testicular torsion in a tropical country. A retrospective study. São Paulo Medical Journal, v.133, n.3, p.187-90, 2015.
GOMES, V.R.; ARIZA, P.C.; SILVA, M.A.M.; SCHULZ JR., F.J.; OLIVEIRA, H.F.; QUEIROZ, L.L.; BORGES, N.C.; BRAGATO, N.; FIORAVANTI, M.C.S. Mineral composition and clinical aspects of urolithiasis in cats in Brazil. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.74, n.4, p.649-661, 2022.
GONÇALVES, B.V.S.; BARBERINI, I.R.; FURTADO, S.K. Urolitíase em felinos: abordagem terapêutica ou cirúrgica? Scire Salutis, v.11, n.2, p.1-13, 2021.
GRIFFETH, R.J.; BIANDA, V.; NEF, S. Theemergingroleof insulin-likegrowthfactorsin testis development and function. Basic and Clinical Andrology, v.24, n.12, p.1-10, 2014.
GRISOLIA, M.; FAYA, M.; MARCHETTI, C.; MERLO, M.L.; D’FRANCISCO, F.; BELLINI, M.J.; GOBELLO, C. Physical, histological, endocrinological and steroidogenical evaluation of male cats postnatally exposed to sexual steroids. Theriogenology, v.138, n.138, p.47-51, 2019.
HORWITZ, D.F. Common feline problem behaviors: urine spraying. Journal of Feline Medicine and Surgery, v.21, n.3, p.209-219, 2019.
JOHNSON, A.K. Normal feline reproduction: The tom. Journal of Feline Medicine and Surgery, v.24, n.3, p.212-220, 2022a.
JOHNSON, A. Clinical approach to infertility in the cat. Clinical Theriogenology, v.14, n.146, p.1-5, 2022b.
JOHNSON, L.; CARTER, G.K.; VARNER, D.D.; TAYLOR, T.S.; BLANCHARD, T.L.; REMBERT, M.S. The relationship of daily sperm production with number of Sertoli cells and testicular size in adult horses: role of primitive spermatogonia. Journal of reproduction and fertility, v.100, n.1, p.315-321, 1994.
JOHNSTON, S.D.; KUSTRITZ, M.V.R.; OLSON, P.N.S. Canine and feline theriogenology. 1. ed. Philadelphia (PA): W. B. Saunders, 2001.
KHONMEE, J.; BROWN, J.L.; PÉREZ, A.L.; LERTWICHAIKULT.; SATHANAWONGS, A.; PORNNIMITRA, P.; AREEWONG, C.; SUPANTA, J.; PUNYAPORNWITHAYA, V.; BUDDHASIRI, S.; PUNTUREE, K. Effect of electroejaculation protocols on semen quality and concentrations of testosterone, cortisol, malondialdehyde, and creatine kinase in captive bengal tigers. Animals, v.13, n.1893, n.1-12, 2023.
KIM, K.; KIM, J.; KIM, H.-Y. Urethral reconstruction combined with modified urethrostomy in a cat after prepubic urethrostomy. Acta Scientiae Veterinariae, v.50, n.1, p.1-2, 2022.
KOEPPEN, B.M.; STANTON, B.A. Berne RM e Levy MN: Fisiologia. 6. ed. Rio de Janeiro: Guanabara Koogan, 2009.
KÖNIG, H.E.; LIEBICH, H.G.. Anatomia dos Animais Domésticos: Texto e Atlas Colorido. 6. ed. Porto Alegre: Artmed Editora, 2016.
KULIBIN, A.Y.; MALOLINA, E.A. In vitro spermatogenesis: In search of fully defined conditions. Frontiers in Cell and Developmental Biology, v.11, p.1-8, 2023.
KUMAR, K.; KANNAN, T.A.; RAMESH, G.; RAO, G.V.R.; RENGASAMY, S., RAVALI, K.S.; ASMITHA, S. Gross morphometric analysis of the testis of tom cats (Felis catus). The Pharma Innovation Journal, v.12, n.5, p.4174-4176, 2023.
LITTLE, S.E. O Gato: Medicina Interna. 1. ed. Rio de Janeiro: Roca, 2016.
LUVONI, G.C.; KALCHSCHMIDT, E.; LEONI, S.; RUGGIERO, C. Conservation of feline semen. Part I: cooling and freezing protocols. Journal of Feline Medicine and Surgery, v.5, n.4, p.203-208, 2003.
MACKIE, P.; CHAN, B.; FRANKE, M.; MASTROMONACO, G.F. Urethral catheterization as an alternative method for collecting sperm in the black-footed ferret (Mustela nigripes). Conservation Physiology, v.8, n.1, p.1-5, 2020.
MACLAUGHLIN, D.T.; TEIXEIRA, J.; DONAHOE, P.K. Perspective: reproductive tract development – new discoveries and future directions. Endocrinology, v.142, n.6, p.2167-2172, 2001.
MADRIGAL-VALVERDE, M.; BITTENCOURT, R.F.; RIBEIRO FILHO, A.D.L.; BARBOSA, V.F.; VIEIRA, C.A.; ROMÃO, E.A.; CARNEIRO, I.B.; AZEVEDO, M.C.; ARAUJO, G.R. Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists. Journal of Feline Medicine and Surgery, v.23, n.8, p.745-750, 2021.
MÄKELÄ, J.A.; J.J. KOSKENNIEMI; VIRTANEN, H.E.; TOPPARI, J. Testis development. Endocrine Reviews, v.40, n.4, p.857-905, 2019.
MARTINS, M.I.M.; ALMEIDA, A.B.M.; HIDALGO, M.M.T. Biotecnologias na preservação de espermatozoides felinos. Ciência Animal, v.32, n.2, p.85-100, 2022.
NANAYAKKARAA, S.D.I.; GIHANB, M.C.; NANAYAKKARAC, P.S.K. A review of scrotal temperature regulation and its importance for male fertility. Sri Lanka Journal of Obstetrics and Gynaecology, v.43, n.4, p.308-313, 2021.
OLIVA, S.U.; RINALDO, P.A.; STUMPP, T. Biologia epididimária: maturação espermática e expressão gênica. Mundo Saúde, v.33, n.4, p.419-425, 2009.
ORR, T.J.; BRENNAN, P.L.R. All features great and small-the potential roles of the baculum and penile spines in mammals. Integrative and Comparative Biology, v.56, n.4, p.635-643, 2016.
PALMIERI, C.; FONSECA-ALVES, C.E.; LAUFER-AMORIM, R. A Review on Canine and Feline Prostate Pathology. Frontiers in Veterinary Science, v.9, n.881232, p.1-12; 2022.
PENG, Y.K.; TANG, X.T.; SHU, H.S.; DONG, W.; SHAO, H.; ZHOU, B.O. Sertoli cells are the source of stem cell factor for spermatogenesis. Development, v.150, n.5, p.1-15, 2023.
PICULO, F.; MARINI, G.; DAMASCENO, D.C.; SINZATO, Y.K.; BARBOSA, A.M.P.; MATHEUS, S.M.M.; RUDGE, M.V.C. Morfologia da uretra. In: Guia ilustrado da morfologia do tecido uretral de ratas. São Paulo: UNESP, 2014.
PIMENTA, M.M.; RECHE-JÚNIOR, A.; FREITAS, M.F.; KOGIKA, M.M.; HAGIWARA, M.K. Estudo da ocorrência de litíase renal e ureteral em gatos com doença renal crônica. Pesquisa Veteterinária Brasileira, v.34, n.6, p.555-561, 2014.
PINTUS, E.; KADLEC, M.; KARLASOVÁ, B.; POPELKA, M.; ROS-SANTAELLA, J.L. Spermatogenic Activity and Sperm Traits in Post-Pubertal and Adult Tomcats (Felis catus): Implication of Intra-Male Variation in Sperm Size. Cells, v.10, n.624, p.2-13, 2021.
POINTIS, G.; FIORINI, C.; DEFAMIE, N.; SEGRETAIN, D. Gap junctional communication in the male reproductive system. Biochimica et Biophysica Acta, v.1719, n.1/2, p.102-116, 2005.
RESTREPO, M.T.; ALTUZARRA, R.; ESPADA, Y.; DOMÍNGUEZ, E.; MALLOL, C.; NOVELLAS, R. CT Characterization of the feline os penis. Journal of Feline Medicine and Surgery, v.22, n.8, p.673-677, 2020.
RUHUI, T; CHENCHENG, Y.; CHAO, Y.; ZIJUE, Z.; CHONG, L.; ERLEI, Z.; JUNLONG, W.; PENG, L.; HUIXING, C.; QINGQING, Y.; ZUPING, H.; ZHENG, L. Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation. Stem Cell Research and Therapy, v.10, n.40, p.1-14, 2019.
SAMPAIO, K.O.; ALEIXO, G.A.S.; SOUSA-FILHO, R.P.; SILVA, E.C.B. Obstrução uretral em gatos. Veterinária e Zootecnia, v.27, p.1-11, 2020.
SÁNCHEZ, A.; TSUTSUI, T. Evaluación de dos diluyentes seminales para preservación refrigerada de espermatozoides de gato (Felis catus). Revista Científica, v.12, n.4, p.249-253, 2002.
SARFRAZ, A.; UMAR, Z. Maintenance of thermal homeostasis with special emphasis on testicular thermoregulation. Acta Veterinaria Eurasia, v.45, n.2, p.63-72, 2019.
SAWAIED, A.; ARAZI, E.; ABUELHIJA, A.; LUNENFELD, E.; HULEIHEL, M. The presence of colony-stimulating factor-1 and its a receptor in different cells of the testis; it involved in the development of spermatogenesis in vitro. International Journal of Molecular Science, v.22, n.5, p. 2325-2338, 2021.
SENGUL, G, ERTEKIN, C. Human cremaster muscle and cremasteric reflex: a comprehensive review. Clinical Neurophysiology, v.131, n.6, p.1354-1364, 2020.
SHAH, W.; KHAN, R.; SHAH, B.; KHAN, A.; DIL, S.; LIU, W.; WEN, J.; JIANG, X. The molecular mechanism of sex hormones on sertoli cell development and proliferation. Frontiers in Endocrinology, v.12, n.648141, p.1-13, 2021.
SILVA, A.F.; ESCADA-REBELO, S.; AMARAL, S.; TAVARES, R.S.; SCHLATT, S.; RAMALHO-SANTOS, J.; MOTA, P.C. Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach? Plos One, v.13, n.2, p.1-14, 2018.
SILVA, L.D.M. Canine and feline testicular preservation. Animals, v.12, n.124, p.1-10, 2022.
SMITH, B.J. The Urogenital System. In: HUDSON, L.C.; HAMILTON, W.P. Atlas of Feline Anatomy. 2. ed. Jackson (WY): Teton NewMedia, cap. 9, p.171-192, 2010.
SWENSON, M.J.; REECE, W.O. Dukes. Fisiologia dos Animais Domésticos. 12. ed. Rio de Janeiro: Guanabara-Koogan, 2007.
TANAKA, T.; KANATSU-SHINOHARA, M.; LEI, Z.; RAO, C.V.; SHINOHARA, T. The luteinizing hormone-testosterone pathway regulates mouse spermatogonial stem cell self-renewal by suppressing WNT5A expression in sertoli cells. Stem Cell Reports, v.7, n.9, p.279-291, 2016.
TSUTSUI, T.; KUWABARA, S.; KUWABARA, K.; KUGOTA, Y.; KINJO, T.; HORI, T. Development of spermatogenic function in the sex maturation process in male cats. Theriogenology, v.66, n.9, p.1125-1127, 2004.
VALENTINI, L.; ZUPA, R.; POUSIS, C.; CUKO, R.; CORRIERO, A. proliferation and apoptosis of cat (Felis catus) male germ cells during breeding and non-breeding seasons. Veterinary Science, v.9, n.447, p.1-8, 2022.
YAN, Y.C.; SUN, Y.P.; ZHANG, M.L. Testis epidermal growth factor and spermatogenesis.
Archives of Andrology, v.40, n.2, p.133-146, 1998.
YANG, Y; FENG, Y; FENG, X.; LIAO, S.; WANG, X.; GAN, H.; WANG, L.; LIN, X.; HAN, C. BMP4 cooperates with retinoic acid to induce the expression of differentiation markers in cultured mouse spermatogonia. Stem Cells International, v.2016, p.1-14, 2016.
YEH, J.R.; ZHANG, X.; NAGANO, M.C. WNT5A is a cell-extrinsic factor that supports self renewal of mouse spermatogonial stem cells. Journal of Cell Science, v.124, n.14, p.2357-2366, 2011.
YIEE, J.H.; BASKIN, L.S. Penile embryology and anatomy. The Scientific World Journal, v.10, p.1174–1179, 2010.
ZAKER, H.; RAZI, M.; MAHMOUDIAN, A.; SOLTANALINEJAD, F. Boosting effect of testosterone on GDNF expression in Sertoli cell line (TM4); comparison between TM3 cells-produced and exogenous testosterone. Gene, v.812, n.20, p.146112, 2022.
