Ovarian tumor of Sertoli cells in a female dog
Keywords:
Bitches, Ovary, Neoplasia, Sexual cord, SertoliomaAbstract
Sertoli cells tumor, classified as a pure sexual cord tumor, is characterized by causing endocrine clinical manifestations. It is commonly found in males and is rare in females. The present study aimed to report a case of a Sertoli cell ovarian tumor in a female dog. The patient was a five-year-old female Shi Tzu dog, who complained of prayer position frequently and anestrus for two years. The physical examination determined diffuse and symmetrical alopecia, skin hyperpigmentation, fragile hair, and comedones, with increased volume in the left flank and sensitivity to abdominal palpation. The ultrasound examination evidenced the presence of a rounded structure, with defined edges in the topography of the left ovary, measuring approximately 5.27cm in its longest axis, in addition to incipient pyometra. After ovariosalpingohysterectomy, a histopathological evaluation of the ovary was performed with a diagnosis of sexual cord/stroma with an infiltrative Sertoli cell pattern. It is concluded that, although uncommon, it is important to include the Sertoli cell tumor as a differential diagnosis in cases of signs of hormonal dysregulation and changes in the estrous cycle, and animal's coat. The importance of imaging and histopathological exams for diagnosis, prognosis, and appropriate treatment is highlighted.
References
AIRES, L.P.N.; PAVAN, L.; GASSER, B.; SILVA, P.; MARONEZI, M.C.; SILVA, P.D.A.; SILVEIRA, M.V.; SANTOS, V.J.C.; NAKAGHI, L.C.P.; POZZOBON, R. Ultrasonographic aspects of the uterus and ovaries of bitches during the estrous cycle paper review. Revista Brasileira de Reprodução Animal, v.45, n.1, p.3-11, 2021.
ARAÚJO, L.M.N.; CASSETARI, H.M.; MATOS, P.S.D.; LEME, L.H.D.S.; PROTA, F.E. Tumor ovariano de células de Sertoli: relato de caso. Revista Brasileira Ginecologia e Obstetrícia, v.15, n.3, p.145-147, 1993.
ARLT, S. P.; HAIMERL, P. Cystic ovaries and ovarian neoplasia in the female dog – a systematic review. Reproduction in Domestic Animals, v. 51, n. 1, p. 3-11, 2016.
BORNOT, R.D.; SAMLALL, S.; NODA, M.F. Tumor de Células de Sertoli del ovario: Reporte de un caso. Revista Habanera Ciências Médicas; v.19, n.2, p.1-9, 2020.
CONTE, F.; BRAVO, S.A.; BORTOLATO, T.L.; FREITAS, I.B.D.; MARKS, D.; GUEDES, R.L. Diagnóstico e tratamento videoassistido de tumor de células de Leydig em cadela com síndrome do ovário remanescente. Ciência Animal, v.31, n.4, p.181-187, 2021.
CORREA, B.R.; CUELLO, F.M.; GEJMAN, E.R.; MERINO, O.P.; ETCHEGARAY, B.A.; CARRASCO, A.M.; BRANES, Y.J. Tumor de células de sertoli y leydig del ovário. Revista Chilena Obstetrícia Ginecologia, v.68, n.5, p.399-406, 2003.
DALECK, C.R.; SOUZA, F.F.D.; MARTINS, M.I.M.; NARDI, A.B.D. Neoplasia do sistema reprodutor feminino. In: DALECK, C.R.; NARDI, A.B.D. Oncologia em cães e gatos. 2ª ed., Rio de Janeiro: Roca, p.545-556, 2017.
DIAZ, I.S.; ALARCÓN, R.H., ARONES, E.T., ZUNIGA, A.L. Tumor de células de Sertoli-Leydig: a propósito de un caso. Revista Peruana Ginecologia Obstetrícia, v.60, n.3, p.152-154, 2014.
DURMUS, Y.; KILIC, C.; CAKIR, C.; YUKSEL, D.; BORAN, N.; KARALÕK, A.; BOYRAZ, G.; TURAN, A.T. Sertoli–Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature. Journal of Obstetrics and Gynaecology Research, v.45, n.7, p.1311-1318, 2019.
LAGUNA, J.G.; MILLÁN, Y.; REYMUNDO, C.; DOMINGO, V.; MULAS, J.M.D.L. Bilateral Retiform Sertoli–Leydig Cell Tumour in a Bitch. Alpha-Inhibin and Epithelial Membrane Antigen as Useful Tools for Differential Diagnosis. Journal of Comparative Pathology, v.139, n.2/3, p.137-140, 2008.
MACLACHLAN, N.J. Ovarian Disorders in Domestic Animals. Environmental Health Perspectives. v.73, n.1, p.27-33, 1987.
PATNAIK, A.K.; SAIGO, P.E.; LIEBERMAN, P.H.; GREENLEE, P.G. Morphology of canine ovarian Sertoli-Leydig cell neoplasms. A report of 12 cases. Cancer, v.1, n.62, p.577-584, 1988.
PERTIWI, H.; SOFYAN, M.S.; DADI, T.B.; ROSMAN, N. KAMALUDEEN, J. A Rare Case of Canine Ovarian Carcinoma Management. Journal of Veterinary and Marine Research. v.1., n.1, p.1-4, 2022.
PODESTÁ, F.S.; CAQUIAS, D.I. Canine ovarian dysgerminoma. Ciência Rural: Santa Maria, v.50, n.1, p.1-5, 2020.
RUSSO, M.; ENGLAND, G.C.W.; CATONE, G.; MARINO, G. Imaging of Canine Neoplastic Reproductive Disorders Animals, v.11, n.5, p.1-12, 2021.
SOUZA, L.D.B.S.; BURGIS, J.T.M.D.; JANICE, L.B.M.D.; CAMPS, J.I.M.D. A Pure Sertoli Cell Tumor of the Ovary in a 10-Year-Old Female. Journal of Pediatric and Adolescent Gynecology, v.20, n.4, p.257-259, 2007.
THONGTHARB, A.; KHUNPRATOOM, K.; PATANADAMRONGCHAI, P.; BOONSRI, K.; PHOSRI, A.; SRIPRATAK, T. Ovarian sex-cord stromal tumor in Yorkshire Terrier dog. Veterinary Integrative Sciences, v.19, n.3, p.295-304, 2021.
TOLOSA, E.M.C.; RODRIGUES, C.J.; BEHMER, O.A.; FREITAS NETO, A.G. Manual de técnicas para histologia normal e patológica. 2a ed., Barueri, Editora Manole, 2003. 331p.
VISSIENNON, T.; SCHMIDT, T.; SCHNEIDER, E.; HILDEBRAND, M. Sertoli Leydig cell tumour in a bitch, 10 years after spaying. A case report. PUBMED, v.38, n.6, p.399-402, 2010.
WASIK, S.M.; BACCI, B.; WITHAM, A.I. Concurrent Sertoli-Leydig cell ovarian tumour and Gartner's duct cyst in an 8-year-old bitch. Australian Veterinary Practitioner, v.44, n.4, p.713- 718, 2014.
