Evaluation of the concentration of lactate dehydrogenase in bitches with mammary gland tumor
Published 2023-01-16
Keywords
- Cancer,
- Glycolysis,
- Prognosis
How to Cite
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
The increase in lactate dehydrogenase (LDH) activity is associated with hypoxia due to the rapid proliferation of cancer cells and high metabolic demands. Few studies have evaluated the LDH concentration in canine mammary tumor (CMT). Thus, the objective of this work was to evaluate serum LDH concentrations in CMT and its association with prognostic factors. Thirty bitches participated in the work and were divided equally into two groups, with and without CMT. The average concentration of LDH was significantly higher in CMT (424.9±244.4 U / L) compared to the control group (299.0±170.3 U / L) and its values were positively correlated with inflammation and / or macroscopic ulceration (r=0.6), tumor size (r=0.5), histopathological grade (r=0.6), metastatic lymph node (r=0.7) and clinical stage (r=0.5).
Downloads
References
- CAMPOS, L.C.; LAVALLE, G.E.; ESTRELA-LIMA, A.; MELGAÇO DE FARIA J.C.; GUIMARÃES J.E.; DUTRA Á.P.; FERREIRA E.; DE SOUSA L.P.; RABELO É.M.L.; VIEIRA DA COSTA A.F.D.; CASSALI G.D. CA15.3, CEA, and LDH 185 in dogs with malignant mammary tumors. Journal of Veterinary Internal Medicine, v.26, p.1383-1388, 2012.
- CASSALI, G.D.; LAVALLE, G.E.; FERREIRA, E.; ESTRELA-LIMA, A.; DE NARDI, A. B.; GHEVER, C.; BESERRA, H.E. Consensus for the diagnosis, prognosis and treatment of canine mammary tumors-2013. Brazilian Journal of Veterinary Pathology, v.7, n.2, p.38-69, 2014.
- CHEN, G.; CAI, Z.; LIN, Z.; WANG, C.; LIANG, Y.; HAN, Z.; ZHONG, W. ARNT‐dependent CCR8 reprogrammed LDH isoform expression correlates with poor clinical outcomes of prostate cancer. Molecular Carcinogenesis, p.1-11, 2020.
- ELSTON, C. W.; ELLIS, I. O. Assessment of histological grade. The breast, v.13, p.356-384, 1998.
- HADDEN, A.G.; COTTER, S.M.; RAND, W.; MOORE, A.S.; DAVIS, R.M.; MORRISSEY, P. Efficacy and toxicosis of VELCAP-C treatment of lymphoma in cats. Journal of Veterinary Internal Medicine, v.22, p.153-157, 2008.
- HSU, P.P.; SABATINI, D.M. Cancer cell metabolism: Warburg and beyond. Cell, v.5, n.134, p.703‐707, 2008.
- HUANG, X.; LI, X.; XIE, X. High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer. Breast, v.30, p.39‐46, 2016.
- KOUKOURAKIS, M.; GIATROMANOLAKI, A.; SIVRIDIS, E. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumor hypoxia, angiogenic factor production and poor prognosis. British Journal of Cancer, v.89, p.877-885, 2003.
- KOUKOURAKIS, M.I.; GIATROMANOLAKI, A.; SIVRIDIS, E.; GATTER, K.C.; HARRIS, A.L. Tumor Angiogenesis Research Group. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway‐a report of the tumor Angiogenesis Research Group. Journal of Clinical Oncology, v.24, n.26, p.4301‐4308, 2006.
- KOUKOURAKIS, M.I.; KONTOMANOLIS, E.; GIATROMANOLAKI, A.; SIVRIDIS, E.; LIBERIS, V. Serum and tissue LDH levels in patients with breast/gynecological cancer and benign diseases. Gynecologic and Obstetric Investigation, v.67, n.3, p.162‐168, 2009.
- MARCONATO, L.; CRISPINO, G.; FINOTELLO, R.; MAZZOTTI, S.; SALERNI, F.; ZINI, E. Serum lactate dehydrogenase activity in canine malignancies. Veterinary and Comparative Oncology, v.7, n.4, p.236–243, 2009.
- ZHAO, D.; ZOU, S.W.; LIU, Y.; ZHOU, X.; MO, Y.; WANG, P.; GUAN, K.L. Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell, v.23, n.4, p.464-476, 2013.