Evaluation of c-kit protein (CD-117) immunostaining in canine mammary tumors
Keywords:
Mammary tumor, CD117, immunohistochemistry, female dogsAbstract
Mammary neoplasms in dogs have a significant relevance in the veterinary clinical routine and the search for new associated factors in its etiopathogenesis and therapy is necessary to enable the study of new more effective therapies. This study aimed to evaluate the behavior of c-kit expression in benign and malignant canine mammary tumors by immunohistochemistry. The samples were evaluated for intensity staining, percentage of labeled cells, to obtain the final score. For the positive control was used a positive mastocytoma sample for c-kit expression. 32 samples of breast carcinomas and five samples of benign breast tumors were used. All tumors express c-kit, with cytoplasmic pattern. Sixteen carcinomas showed a low score of immunostaining and 16 had high scores. All benign breast tumors had high immunostaining score. Expression of c-kit was greater in tumors compared to benign malignant tumors. The anaplastic carcinomas showed high final score and grade III. suggesting greater expression in this tumor type.
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