Pets and COVID-19: domestic dogs and cats and their connections to the new human coronavirus

Authors

  • Klena Sarges Marruaz da Silva Instituto de Ciência e Tecnologia em Biomodelos da Fundação Oswaldo Cruz
  • Luiz Ricardo Berbert Coordenação de Atividades com Modelos Biológicos Experimentais da Universidade Federal do Rio de Janeiro

Keywords:

COVID-19, dogs, cats, pets, epidemiology

Abstract

The Novel Coronavirus SARS-CoV-2 pandemic still raises questions in the scientific community about the source of disease contamination, and confirmation of COVID-19 as a new anthropozoonosis, which seeks to understand the role of animals in the beginning and maintainance of the pandemic cycle. Specially, dogs and cats are of greater concern because of their close, almost uninterrupted, contact with humans sharing the same environment, thus increasing their risk of exposure to the pathogen. In these animals, other strains of coronavirus are known to cause species-specific diseases, such as respiratory canine coronavirus and enteric canine coronavirus in dogs and feline coronavirus in cats. However, both can occasionally cause disease only in other species of non-human animals. Some reports of natural SARS-CoV-2 infection in dogs and cats have been published, as well as investigations into the susceptibility of these species to the virus. International human and animal health surveillance institutions have also commented on the relationship between domestic animals and COVID-19. This review intends to update the reader about SARS-CoV-2 infections in the context of dogs and cats, discussing the connections between these animals and the new human coronavirus and warning about the inappropriate and unnecessary abandonment of these animals during the COVID-19 pandemic.

References

ALMENDROS, A. Can companion animals become infected with Covid-19? Veterinary Record, v.186, n.12, p. 388-389, 2020.

AVMA. American Veterinary Medical Association. SARS-CoV-2 in animals. Acesso em 11 de junho de 2020. Disponível em: https://www.avma.org/resources-tools/animal-health-and-welfare/covid-19/sars-cov-2-animals-including-pets

BERBERT, L.R.; CAMPBELL, D.; MARTINS, F.; PARREIRAS, L.; BARBOSA, M.J.; NOGUEIRA, M.S.; CARVALHO, N.L.; UHL, R.; SILVA, K.S.M. Biomodelos e a COVID-19: Estado da Arte e Tendências de Uso. Revista da Sociedade Brasileira em Ciências de Animais de Laboratório, v.8, n.1, p.19-32, 2020.

BOSCO-LAUTH, A.M.; HARTWIG, A.E.; PORTER, S.M.; GORDY, P.W.; NEHRING, M.; BYAS, A.D.; VANDEWOUDE, S.; RAGAN, I. K.; MAISON, R. M.; BOWEN, R. A. Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats. Proceedings of the National Academy of Sciences USA, v.117, n.42, p.26382-26388, 2020.

CDC. Control Disease Center. Confirmation of COVID-19 in Two Pet Cats in New York. 2020. Acesso em 22 de abril de 2020. Disponível em: https://www.cdc.gov/media/releases/ 2020/s0422-covid-19-cats-NYC.html

CDC. Control Disease Center. Interim Guidance for Public Health Professionals Managing People With COVID-19 in Home Care and Isolation Who Have Pets or Other Animals. Acesso em 15 de maio de 2020. Disponível em: https://www.cdc.gov/coronavirus/2019-ncov/ animals/interim-guidance-managing-people-in-home-care-and-isolation-who-have-pets.html

CSISZAR, A.; JAKAB, F.; VALENCAK, T.G.; LANSZKI, Z.; TÓTH, G.E.; KEMENESI, G; TARANTINI, S.; FAZEKAS-PONGOR, V.; UNGVARI, Z. Companion animals likely do not spread COVID-19 but may get infected themselves. Geroscience, v.42, n.5, p.1229-1236, 2020.

DALY, N. Seven more big cats test positive for coronavirus at Bronx Zoo. National Geographic. Acesso em 01 de outubro de 2020. Disponível em: https://www.nationalgeographic.com/animals/2020/04/tiger-coronavirus-COVID-19-positive-test-bronx-zoo/

DAMAS, J.; HUGHES, G.M.; KEOUGH, K.C.; PAINTER, C.A.; PERSKY, N.S.; CORBO, M.; HILLER, M.; KOEPFLI, K.P.; PFENNING, A.R.; ZHAO, H.; GENEREUX, D.P.; SWOFFORD, R.; POLLARD, K.S.; RYDER, O.A.; NWEEIA, M.T.; LINDBLAD-TOH, K.; TEELING, E.C.; KARLSSON, E.K.; LEWIN, H.A. Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates. Proceedings of the National Academy of Sciences, v.117, n.36, p.22311-22322, 2020.

DENG, J.; JIN, Y.; LIU, Y.; SUN, J.; HAO, L.; BAI, J.; HUANG, T.; LIN, D.; JIN, Y.; TIAN, K. Serological survey of SARS-CoV-2 for experimental, domestic, companion and wild animals excludes intermediate hosts of 35 different species of animals. Transboundary Emerging Diseases, v.67, n.4, p.1745-1749, 2020.

GAO, T.; PAN, X.; PAN, C. The fate of house cats during the COVID-19 pandemic. Microbes Infection, v.22, n.4-5, p.157, 2020.

GUO, Y.R.; CAO, Q.D.; HONG, Z.S.; TAN, Y.Y.; CHEN, S.D.; JIN, H.J.; TAN, K.S.; WANG, D.Y.; YAN, Y. The origin, transmission, and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Military Medical Research, v.7, n.11, 2020.

HALFMANN, P.J.; HATTA, M.; CHIBA, S.; MAEMURA, T.; FAN, S.; TAKEDA, M.; KINOSHITA, N.; HATTORI, S.I.; SAKAI-TAGAWA, Y.; IWATSUKI-HORIMOTO, K.; IMAI, M.; KAWAOKA, Y. Transmission of SARS-CoV-2 in Domestic Cats. New England Journal of Medicine, v.383, n.6, p.592-594, 2020.

HUANG, Q.; XIANG, Z.; XIAN-TAO, Z. COVID-19 pandemic: stop panic abandonment of household pets. Journal of Travel Medicine, v.27, n.3, p.46-46, 2020.

JENDRNY, P.; SCHULZ, C.; TWELE, F.; MELLER, S.; VON KÖCKRITZ-BLICKWEDE, M.; OSTERHAUS, A.; EBBERS, J.; PILCHOVÁ, V.; PINK, I.; WELTE, T.; MANNS, M. P.; FATHI, A.; ERNST, C.; ADDO, M.M.; SCHALKE, E.; VOLK, H.A. Scent dog identification of samples from COVID-19 patients - a pilot study. BMC Infectious Diseases, v.20, n.536, p.1-7, 2020.

JONES, R.T.; GUEST, C.; LINDSAY, S.W.; KLEINSCHMIDT, I.; BRADLEY, J.; DEWHIRST, S.; A.L.A.; LOGAN, J.G. Could bio-detection dogs be used to limit the spread of COVID-19 by travellers? Journal of Travel Medicine, n. taaa131, p.1-11, 2020.

LAM, S.D.; BORDIN, N.; WAMAN, V.P.; SCHOLES, H.M.; ASHFORD, P.; SEN, N.; VAN DORP, L.; RAUER, C.; DAWSON, N.L.; PANG, C.S.M.; ABBASIAN, M.; SILLITOE, I.; EDWARDS, S.J.L.; FRATERNALI, F.; LEES, J.G.; SANTINI, J.M.; ORENGO, C.A. SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals. BioRxiv, v.10, n.16471, p.1-14, 2020.

LAROUCHE-LEBEL, É.; LOUGHRAN, K.A.; OYAMA, M.A.; SOLTER, P.F.; LAUGHLIN, D.S.; SÁNCHEZ, M.D.; ASSENMACHER, C.A.; FOX, P.R.; FRIES, R.C. Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease. Journal of Veterinary Internal Medicine, v.33, n.4, p.1571–1584, 2019.

LI, X. Cats under the shadow of the SARS-CoV-2 pandemic. Transboundary and Emerging Diseases, v.67, n.4, p.1416-1417, 2020.

LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE. Using dogs to detect COVID-19 Acesso em 10 de setembro de 2020. Disponível em: https://www.lshtm.ac.uk/research/centres-projects-groups/using-dogs-to-detect-covid-19

MASTERS, P.S.; PERLMAN, S. Coronaviridae. Fields Virology, v. 1, p. 825-858, 2013.

OIE. World Organization for Animal Health. COVID-19 Portal. 2020. Acesso em 09 de junho de 2020. Disponível em: https://www.oie.int/en/scientific-expertise/specific-information-and-recommendations/questions-and-answers-on-2019novel-coronavirus/

OPAS. Organização Panamericana de Saúde. Folha informativa COVID-19 - Escritório da OPAS e da OMS no Brasil. Acesso em 02 de outubro de 2020. Disponível em: https://www.paho.org/pt/COVID-19#animal

PARRY, N.M.A. COVID-19 and pets: When pandemic meets panic. Forensic Science International: Reports, v.2, n.100090, p.1-4, 2020.

PATTERSON, E.I.; ELIA, G.; GRASSI, A.; GIORDANO, A.; DESARIO, C.; MEDARDO, M.; SMITH, S.L.; ANDERSON, E.R.; PRINCE, T.; PATTERSON, G.T.; LORUSSO, E.; LUCENTE, M.S.; LANAVE, G.; LAUZI, S.; BONFANTI, U.; STRANIERI, A.; MARTELLA, V.; BASANO, F.S.; BARRS, V,.R.; RADFORD, A.D.; AGRIMI, U.; HUGHES, G.L.; PALTRINIERI, S.; DECARO, N. Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy. Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy. BioRxiv, n.214346, p.1-17, 2020.

PEDERSEN, N.C. An update on feline infectious peritonitis: diagnostics and therapeutics. Veterinary Journal, v.201, n.2, p.133-141, 2014.

RAYNOR, B.; DÍAZ, E.W.; SHINNICK, J.; ZEGARRA, E.; MONROY, Y.; MENA, C.; CASTILLO-NEYRA, R. The impact of the COVID-19 pandemic on rabies reemergence in Latin America: the case of Arequipa, Peru. MedRxiv, n. 20169581, p.1-16, 2020.

REVISTA CÃES E GATOS. Estudo analisa comportamento de tutores de pets na pandemia. 2020. Acesso em 10 de junho de 2020. Disponível em: http://www.caesegatos.com.br/ noticia/estudo-analisa-comportamento-d-tutores-de-pets-na-pandemia

SAILLEAU, C.; DUMAREST, M.; VANHOMWEGEN, J.; DELAPLACE, M.; CARO, V.; KWASIBORSKI, A.; HOURDEL, V.; CHEVAILLIER, P.; BARBARINO, A.; COMTET, L.; POURQUIER, P.; KLONJKOWSKI, B.; MANUGUERRA, J.C.; ZIENTARA, S.; LE PODER, S. First detection and genome sequencing of SARS-CoV-2 in an infected cat in France. Transboundary Emerging Diseases, n.10.1111/tbed.13659, p.1-12, 2020.

SEGALÉS, J.; PUIG, M.; RODON, J.; AVILA-NIETO, C.; CARRILLO, J.; CANTERO, G.; TERRÓN, M.T.; CRUZ, S.; PARERA, M.; NOGUERA-JULIÁN, M.; IZQUIERDO-USEROS, N.; GUALLAR, V.; VIDAL, E.; VALENCIA, A.; BLANCO, I.; BLANCO, J.; CLOTET, B.; VERGARA-ALERT, J. Detection of SARS-CoV-2 in a cat owned by a COVID-19-affected patient in Spain. Proceedings of National Academy of Sciences USA, v.117, n.40, p.24790-24793, 2020.

SHI, J.; WEN, Z.; ZHONG, G.; YANG, H.; WANG, C.; HUANG, B.; LIU, R.; HE, X.; SHUAI, L.; SUN, Z.; ZHAO, Y.; LIU, P.; LIANG, L.; CUI, P.; WANG, J.; ZHANG, X.; GUAN, Y.; TAN, W.; WU, G.; CHEN, H.; BU, Z. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2. Science, v.368, n.6494, p.1016-1020, 2020.

STEVENS, A. AJC. Atlanta News Now. Georgia dog tests positive for virus that causes COVID-19. 2020. Acesso em 01 de julho de 2020. Disponível em: https://www.ajc.com/news/local/breaking-georgia-dog-tests-positive-for-virus-that-causescovid/Yilt051pRyYPEVb0Ycl92O/?fbclid=IwAR3Af3vUC1Pa4DoPG0DXPwD4vp60j_TuB25hjdfDpFShT8XwruwMfEfmNvc

STOUT, A.E.; ANDRÉ, N.M.; JAIMES, J.A.; MILLET, J.K.; WHITTAKER, G.R. Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit? Veterinary Microbiology., v.247, n.108777, p.1-6, 2020.

SYKES, J.E. Canine and Feline Infectious Diseases. 1st ed., Saint Louis: Elsevier Saunders, 2013. 928p.

THE BRUSSELS TIMES. Coronavirus: Belgian woman infected her cat. 2020. Acesso em 21 de março de 2020. Disponível em: https://www.brusselstimes.com/all-news/belgium-allnews/103003/coronavirus-belgian-woman-infected-her-cat/

THE GUARDIAN. Close to 100% accuracy': Helsinki airport uses sniffer dogs to detect Covid. Acesso em 30 de setembro de 2020. Disponível em: https://www.theguardian. com/world/2020/sep/24/close-to-100-accuracy-airport-enlists-sniffer-dogs-to-test-for-covid-19

USDA. United States Department of Agriculture. Confirmed cases of SARS-CoV-2 in Animals in the United States. Acesso em 01 de outubro de 2020. https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/SA_One_Health/sars-cov-2-animals-us

WAN, Y.; SHANG, J; GRAHAM, R.; BARIC, R.S; LI F. Receptor Recognition by the Novel Coronavirus from Wuhan: An Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. Journal of Virology, v.94, n.7, p.1-9, 2020.

WANG, C.; TAN, Y.D.; GUO, A.Z.; CHEN, H.C. Domestic cat ACE2 gene cloning, sequencing and bioinformatic analysis. Wuhan University. Journal. 2005. Acesso em 20 de setembro de 2020. Disponível em: https://en.cnki.com.cn/Article_en/CJFDTOTAL-WHDY200506018.htm

WANG, H.; WANG, F.; WANG, H; ZHAO, Q. Potential infectious risk from the pets carrying SARS-CoV-2. Travel Medicine and Infectious Disease, v.35, n.101737, 2020.

WATSON, K.M.; ZHANG, Y.; TOWNS, K.; KAHE, K. Owner concerns that pets have Covid-19. Veterinary Record, v.186, n.18, p.608-609, 2020.

WHO. World Health Organization. Consensus Document on the Epidemiology of Severe Acute Respiratory Syndrome (SARS). 2003. Acesso em 15 de setembro de 2020. Disponível em: https://apps.who.int/iris/handle/10665/70863

WORLD HEALTH ORGANIZATION. EASTERN MEDITERRANEAN REGIONAL OFFICE. Zoonotic disease: emerging public health threats in the Region. Acesso em 20 de maio de 2020. Disponível em: http://www.emro.who.int/fr/about-who/rc61/zoonotic-diseases.html

YUAN, B.; LIU, H.; YANG, Z.; CHEN, Y.; LIU, Z.; ZHANG, K.; WANG, C.; LI, W.; AN, Y.; WANG, J.; SONG, S. Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation. Scientific Reports, v.10, p.11887, 2020.

ZHAI, X.; SUN, J.; YAN, Z.; ZHANG, J.; ZHAO, J.; ZHAO, Z.; GAO, Q.; HE, W.T.; VEIT, M.; SU, S. Comparison of SARS-CoV-2 spike protein binding to ACE2 receptors from human, pets, farm animals, and putative intermediate hosts. Journal of Virology, v.94, n.15, p.1-20, 2020.

ZHANG, Q.; ZHANG, H.; HUANG, K.; YANG, Y.; HUI, X.; GAO, J.; HE, X.; LI, C.; GONG, W.; ZHANG, Y.; PENG, C.; GAO, X.; CHEN, H.; ZOU, Z.; SHI, Z.; JIN, M. SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation. BioRxiv, n.021196, p.1-12, 2020.

Published

2022-11-10

How to Cite

SILVA, K. S. M. da; BERBERT, L. R. . Pets and COVID-19: domestic dogs and cats and their connections to the new human coronavirus. Ciência Animal, [S. l.], v. 31, n. 2, p. 142–156, 2022. Disponível em: https://revistas.uece.br/index.php/cienciaanimal/article/view/9365. Acesso em: 19 jul. 2024.