Systemic arterial hypertension in cats
Keywords:
Cardiovascular, feline, target organdamage, bloodpressureAbstract
Systolic arterial hypertensionisoftenrecognized in theclinicalpracticeoffelineinternal medicine andis a common problem in oldercats. Thisdiseaseisusuallysecondarytootherdiseases, such as chronickidneydiseaseandhyperthyroidism. However, in some patientstheunderlying cause isnotidentified, thereforecalledidiopathichypertension. Elevations in bloodpressure, whethersustainedornot, can cause damagetovariousorganssuch as thebrain, eyes, heartandkidneys. These injuries are called target organdamage. Systemicbloodpressureabove 160mmHg has a moderatetosevereriskofdamageto target organs. In thisway, thetreatmentideallyseekstoachieverisksofcognitivedamage. Pharmacologicalsubstancescanbeused as antihypertensivetherapy, amongthem, anamlodipine, a calciumchannelblocker, whichisthedrugofchoice for treatment in cats. In addition, it isextremelyimportantto diagnose diseasesthat cause hypertensionortobeassociatedwith it, sothatthisformofbloodpressureisadequate. Early diagnosisofthediseaseisessentialbecause it helps toreducethe chances of target organdamage, andconsequently, reducemortalityand improve patients' qualityoflife.
References
ACIERNO, M.J.; BROWN, S.; COLEMAN, A.E.; JEPSON, R.E.; PAPICH, M.; STEPIEN, R.L.; SYME, H.M. ACVIM consensus statement: Guidelines for theidentification, evaluation, and management ofsystemichypertension in dogs andcatsJournalofVeterinaryInternal Medicine, v.32, n.6, p.1803-1822, 2018.
BIJSMANS, E.S.; JEPSON, R.E.; CHANG, Y.M.; SYME, H.M.; ELLIOTT, J. Changes in SystolicBloodPressure over Time in Healthy Cats and Cats withChronicKidneyDisease. J VetIntern Med, v.29, n.3, p. 855–861, 2015.
BIJSMANS, E.S.; DOING, M.; JEPSON, R.E.; SYME, H.M.; ELLIOTT, J.; PELLIGAND, L. FactorsInfluencingtheRelationshipBetweenthe Dose ofAmlodipineRequired for BloodPressureControlandChange in BloodPressure in Hypertensive Cats. Journal of VeterinaryInternal Medicine, v.30, n.5, p.1630–1636, 2016.
BIJSMANS, E.S.; JEPSON, R.E., WHEELER, C.; SYME, H.M.; ELLIOTT, J. Plasma N-Terminal ProbrainNatriureticPeptide, Vascular EndothelialGrowth Factor, andCardiacTroponin I as Novel BiomarkersofHypertensiveDiseaseand Target OrganDamage in Cats. Journal of VeterinaryInternal Medicine, v.31, n.3, p.650–660, 2017.
CARTER, J.; IRVING, A.; BRIDGES, J.; JONES, B. The prevalenceof ocular lesionsassociatedwithhypertension in a populationofgeriatriccats in Auckland, New Zealand. New Zealand VeterinaryJournal, v.62, n.1, p.21–29, 2014.
CHETBOUL, V.; LEFEBVRE, H.P.; PINHAS, C.; CLERC, B., BOUSSOUF, M.; POUCHELON, J.L. SpontaneousFelineHypertension: ClinicalandEchocardiographicAbnormalities, andSurvival Rate. Journal of VeterinaryInternal Medicine, v.17, n.1, p.89–95, 2003.
COLE, L.; JEPSON, R.; HUMM, K. Systemichypertension in catswithacutekidneyinjury. JournalofSmall Animal Practice, v.58, n.10, p.577-581, 2017.
COLEMAN, A.E.; BROWN, S.A.; STARK, M.; BRYSON, L.; ZIMMERMAN, A.; ZIMMERING, T.; TRAAS, A.M. Evaluationoforallyadministeredtelmisartan for thereductionofindirectsystolic arterial bloodpressure in awake, clinically normal cats. JournalofFeline Medicine andSurgery, v.21, n.2, p.1-6, 2018.
CONROY, M.; CHANG, Y.M.; BRODBELT, D.; ELLIOTT, J. Survivalafterdiagnosisofhypertension in catsattendingprimarycarepractice in the United Kingdom. Journal of VeterinaryInternal Medicine, v.32, n.6, p.1846-1855, 2018.
DAVY, K.P.; HALL, J.E. Obesityandhypertension: Twoepidemicsorone? American JournalPhysiologyRegulatory, IntegrativeandComparativePhysiology, v.286, n.5, p.803–813, 2004.
DESMET, L.; MEER, J.V.D. Antihypertensivetreatmentwithtelmisartan in a catwithamlodipine-inducedgingivalhyperplasia. JournalofFeline Medicine andSurgery Open Reports, v.3, n.2, p.1-5, 2017.
FERREIRA, A.; SOTTIAUX, J.; MANDARA, M.T.; MOTTA, L. Ascendinghaemorrhagicmyelomalaciaassociatedwithsystemichypertension in a hyperthyroid cat. JournalofFeline Medicine andSurgery Open Reports, v.1, n.1, p.1-6, 2015.
GLAUS, T.M.; ELLIOTT, J.; HERBERICH, E.; ZIMMERING, T.; ALBRECHT, B. Efficacyoflong-term oral telmisartantreatment in catswithhypertension: Resultsof a prospectiveEuropeanclinicaltrial. Journal of VetrinaryInternal Medicine, v.33, n.2, p.413-422, 2019.
GOUNI, V.; TISSIER, R.; MISBACH, C.; BALOUKA, D.; BUENO, H.; POUCHELON, J.; LEFEBVRE, H.P.; CHETBOUL, V. Influenceoftheobserver’slevelofexperience on systolicanddiastolic arterial bloodpressuremeasurementsusing Doppler ultrasonography in healthyconsciouscats. JournalofFeline Medicine andSurgery, v.17, v.2, p.94-100, 2015.
HENIK, R.A.; STEPIEN, R.L.; WENHOLZ, L.J.; DOLSON, M.K. Efficacyof atenolol as a single antihypertensiveagent in hyperthyroidcats. JournalofFeline Medicine andSurgery, v.10, n.6, p.577-582, 2008.
Randomized Placebo-ControlledClinicalTrialof a Chewable
FormulationofAmlodipine for theTreatmentofHypertension in
Client-Owned Cats
Randomized Placebo-ControlledClinicalTrialof a Chewable
FormulationofAmlodipine for theTreatmentofHypertension in
Client-Owned Cats
Randomized Placebo-ControlledClinicalTrialof a Chewable
FormulationofAmlodipine for theTreatmentofHypertension in
Client-Owned Cats
Randomized Placebo-ControlledClinicalTrialof a Chewable
FormulationofAmlodipine for theTreatmentofHypertension in
Client-Owned Cats
Randomized Placebo-ControlledClinicalTrialof a Chewable
FormulationofAmlodipine for theTreatmentofHypertension in
Client-Owned Cats
Randomized Placebo-ControlledClinicalTrialof a Chewable
FormulationofAmlodipine for theTreatmentofHypertension in
Client-Owned Cats
HUHTINEN, M.; DERRÉ, G.; RENOLDI, H.J.; RINKINEN, M.; ADLER, K.; ASPEGUÉN, J.; ZEMIRLINE, C.; ELLIOTT, J. Randomized Placebo-ControlledClinicalTrialof a ChewableFormulationofAmlodipine for theTreatmentofHypertension in Client-Owned Cats. Journal of VeterinaryInternal Medicine, v.29, n.3, p.786-793, 2015.
JENKINS, T.L.; COLEMAN, A.E.; SCHMIEDT, C.W.; BROWN, S.A. Attenuationofthe pressor response toexogenousangiotensinbyangiotensin receptor blockersandbenazeprilhydrochloride in clinically normal cats. American Journal of VeterinaryResearch, v.76, n.9, p.807-813, 2015.
JEPSON, R.E.; ELLIOTT, J.; BRODBELT, D.; SYME, H.M. Effectofcontrolofsystolicbloodpressure on survival in catswithsystemichypertension. Journal of VeterinaryInternal Medicine, v.21, n.3, p.402-409, 2007.
Guidelines for theIdentification, Evaluation, and Management of
SystemicHypertension in Dogs and Cats
Guidelines for theIdentification, Evaluation, and Management of
SystemicHypertension in Dogs and Cats
Guidelines for theIdentification, Evaluation, and Management of
SystemicHypertension in Dogs and Cats
Guidelines for theIdentification, Evaluation, and Management of
SystemicHypertension in Dogs and Cats
JEPSON, R.E. Felinesystemichypertension: classificationandpathogenesis. JournalofFeline Medicine andSurgery, v.13, n.1, p.25–34, 2011.
KOHNKEN, R.; SCANSEN, B.A.; PREMANANDAN, C. Vasa VasorumArteriopathy: RelationshipWithSystemic Arterial Hypertensionand Other Vascular Lesions in Cats. VeterinaryPathology, v.54, n.3, p.475–483, 2016.
MAGGIO, F.; DEFRANCESCO, T.C.; ATKINS, C.E.; PIZZIRANI, S.; GILGER B.C.; DAVIDSON, M.G. Ocular lesionsassociatedwithsystemichypertension in cats: 69 cases (1985-1998). Journalofthe American Veterinary Medical, v.217, n.5, p.695–702, 2000.
O’NEILL, J.; KENT, M.; GLASS, E.N.; PLATT, S.R. Clinicopathologicand MRI CharacteristicsofPresumptiveHypertensiveEncephalopathy in Two Cats andTwo Dogs. Journal of the American Animal Hospital Association, v.49, n.6, p.412–420, 2013.
PAYNE, J.R.; BRODBELT, D.C.; FUENTES, V.L. BloodPressureMeasurements in 780 ApparentlyHealthy Cats. Journal of VeterinaryInternal Medicine, v.31, n.1, p.15-21, 2017.
RITMAN EL; LERNAN A. The dynamic vasa vasorum. Cardiovascular Research, v.75, n.4, p.649–658, 2007.
SENT, U.; GOSSL R.; ELLIOTT, J.; SYME, H.M.; ZIMMERING, T. Comparisonofefficacyoflong-term oral treatmentwithtelmisartanandbenazepril in catswithchronickidneydisease. Journal of VeterinaryInternal Medicine, v.29, n.6, p.1479-1487, 2015.
STEELE, J.L.; HENIK, R.A.; STEPIEN, R.L. Effectsofangiotensin-convertingenzymeinhibition on plasma aldosteroneconcentration, plasma reninactivity, andbloodpressure in spontaneouslyhypertensivecatswithchronic renal disease. Veterinarytherapeutics: research in appliedveterinary medicine, v.3, n.2, p.157-166, 2002.
WILLIAMS, T.L.; ELLIOTT, J.; SYME, H.M. Renin-Angiotensin-Aldosterone System Activity in Hyperthyroid Cats withandwithoutConcurrentHypertension. Journal of VeterinaryInternal Medicine, v.27, n.3, p.522–529, 2013.