ASSOCIATION OF NYSTATIN AND SODIUM BENZOATE IN THE TREATMENT OF MACRORHABIDOSE IN COCKATIEL IN NORTHEAST BRAZIL

Authors

  • Ana Caroline Freitas Caetano de SOUSA SOUSA Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • Wanderson Lucas Alves dos SANTOS Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • Ana Carolina Souza MAIA Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • Raimundo Marcel Gomes PRACIANO Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • João Augusto Rodrigues Alves DINIZ Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • Amanda de Carvalho MOREIRA Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • Fabiano Rocha PRAZERES JÚNIOR Postgraduate Program in Biology Parasites, Universidade Federal de Sergipe
  • Carlos Iberê Alves FREITAS Dpt of Health Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN
  • Juliana Fortes Vilarinho BRAGA Dpt o of Animal Sciences, Universidade Federal Rural do Semi-Árido, Mossoró/RN

Keywords:

Avian clinic, alternative therapy, gastrointestinal

Abstract

Macrorhabidosis is an infection caused by Macrorhabdus ornithogaster, an opportunistic ascomycete yeast mainly found in the digestive system of birds. Macrorhabidosis presents high morbidity and variable mortality, with death reported more frequently in young and immunosuppressed birds. It can be treated with antifungals; however, resistance to these drugs has been described, which has driven the development of alternative treatments, such as sodium benzoate. This paper presents the first report of macrorhabidosis in cockatiel and describes the treatment protocol, which included nystatin and sodium benzoate and led to complete recovery. A cockatiel with a history of progressive weight loss was treated at a veterinary clinic, and examination showed that it was apathetic, thin, and presented signs of regurgitation. Samples of the ingluvial contents were collected for cytological examination, from which microorganisms compatible with M. ornithogaster were identified. Along with supportive therapy, nystatin-based treatment was administered; however, due to the lack of improvement in clinical conditions, sodium benzoate was added to the protocol. After 21 days of treatment, the bird recovered and a marked reduction of M. ornithogaster in the animal's microbiota was observed. The results suggest that the inclusion of sodium benzoate contributed to the treatment's success.

References

ALMEIDA, A.O.; MEDEIROS, K.B.R.; MACIEL, J.R.N.; LEAL, E.S.; PINHEIRO, E.C.

Megabacteriose em Calopsita (Nymphicus Hollandicus). Ciência Animal, v.29, n.2, p.05-08,

BORRELLI, L.; DIPINETO, L.; RINALDI, L.; ROMANO, V.; NOVIELLO, E.; MENNA, L.

F.; CRINGOLI, G.; FIORETTI, A. New Diagnostic Insights for Macrorhabdus ornithogaster

Infection. Journal of Clinical Microbiology, v.53, n.11, p.3448-3450, 2015.

CARVALHO, P.R.; QUEIRÓS, T.S.; PITA, M.C.G. Megabacteriose em aves. Pesquisa &

Tecnologia, v.8, n.2, p.1-2, 2011.

GRESPAN, A.; RASO, T.F. Psittaciformes (araras, papagaios, periquitos, calopsitas e

cacatuas). In: CUBAS, Z.S.; SILVA, J.C.R.; CATÃO-DIAS, J.L. Tratado de Animais

Selvagens: Medicina Veterinária. 2. ed., São Paulo: Roca, v.1, cap.28, 2014. p.550-589.

HARRISON, G.J.; LIGHTFOOT, T.L. Clinical Avian Medicine. 2. ed., Palm Beach, FL: Spix

Publishing, 2006.

LANZAROT, P.; BLANCO, J.L.; ALVAREZ-PEREZ, S.; ABAD, C.; CUTULI, M.T.;

GARCIA, M.E. Prolonged Fecal Shedding of Megabacteria’ (Macrorhabdus ornithogaster) by

Clinically Healthy Canaries (Serinus canaria). Medical Mycology, v.51, n.8, p.888-891, 2013.

MADANI, S.A.; GHORBANI, A.; ARABKHAZAELI, F. Successful Treatment of

Macrorhabdosis in Budgerigars (Melopsittacus undulatus) Using Sodium Benzoate. Journal

of Mycology Research, v.1, n.1, p.21-27, 2014.

MARTINS, N.R.S.; HORTA, A.C.; SIQUEIRA, A.M.; LOPES, S.Q.; RESENDE, J.S.;

JORGE, M.A.; ASSIS, R.A.; MARTINS, N.E.; FERNANDES, A.A.; BARRIOS, P.R.;

COSTA, T.J.R.; GUIMARÃES, L.M.C. Macrorhabdus ornithogaster in Ostrich, Rhea,

Canary, Zebra finch, Free range chicken, Turkey, Guinea-fowl, Columbina pigeon, Toucan,

Chuckar Partridge and Experimental Infection in Chicken, Japanese Quail and Mice. Arquivo

Brasileiro de Medicina Veterinaria e Zootecnia, v.58, n.3, p.291-298, 2006.

MOORE, R.P.; SNOWDEN, K.F.; PHAKEN, D.N.A. Method of Preventing Transmission of

So-called 'Megabacteria' in Budgerigars (Melopsittacus undulates). Journal of Avian

Medicine and Surgery, v.15, n.4, p.283-287, 2001.

OZMEN, O.; AYDOGAN, A.H.M.E.T.; HALIGUR, M.E.H.M.E.T.; ADANIR, R.; KOSE, O.;

SAHINDURAN, S. The Pathology of Macrorhabdus ornithogaster and Eimeria Dunsingi (Farr,

Infections in Budgerigars (Melopsittacus undulatus). Israel Journal of Veterinary

Medicine, v.68, n.4, p.218-224, 2013.

PHALEN, D. Diagnosis and Management of Macrorhabdus ornithogaster (formerly

megabacteria). Veterinary Clinics: Exotic Animal Practice, v.8, n.2, p.299-306, 2005.

PHALEN, D.N. Update on the Diagnosis and Management of Macrorhabdus ornithogaster

(formerly megabacteria) in Avian Patients. Veterinary Clinics of North America: Exotic

Animal Practice, v.17, n.2, p.203-210, 2014.

PÜSTOW, R.; KRAUTWALD-JUNGHANNS, M.E. The Incidence and Treatment Outcomes

of Macrorhabdus ornithogaster Infection in Budgerigars (Melopsittacus undulatus) in a

Veterinary Clinic. Journal of Avian Medicine and Surgery, v.31, n.4, p.344-350, 2017.

RAJABI, E., NABIPOUR, A. Histological Study on the Oesophagus and Crop in Various

Species of Wild Bird. Avian Biology Research, v.2, n.3, p.161-164, 2009.

SEGABINAZI, S.D.; FLÔRES, M.L.; KOMMERS, G.D.; BARCELOS, A.D.S.; VEIT, D.C.;

ELTZ, R.D. Megabacteriose em emas (Rhea americana) no Estado do Rio Grande do Sul,

Brasil. Ciência Rural, v.34, n.3, p.959-960, 2004.

SILVA, C.S.; LALLO, M.A.; BENTUBO, H.D.L. Megabacteriose aviária: breve revisão.

Research, Society and Development, v.11, n.1, p.1-14, 2022.

WERTHER, K.; SCHOCKEN-ITURRINO, R.P.; VERONA, C.E.S.; BARROS, L.S.S.

Megabacteriosis Occurrence in Budgerigars, Canaries and Lovebirds in Ribeirão Preto region-

São Paulo state-Brazil. Revista Brasileira de Ciência Avícola, v.2, n.2, p.183-187, 2000.

HOPPES, S. Treatment of Macrorhabdus ornithogastor with sodium benzoate in budgerigars

(Melopsittacus undulates). Proceedings of the 23 rd Annual Conference of the Association of

Avian Veterinarians. Association of Avian Veterinarians, Seattle (WA), 2012.

WIBBERTMANN, A.; KIELHORN, J.; KOENNECKER, G.; MANGELSDORF, I.;

MELBER, C. Benzoic acid and sodium benzoate (n o 26). In: World Health Organization, 2000.

Published

2025-07-01

How to Cite

SOUSA, A. C. F. C. de S.; SANTOS, W. L. A. dos; MAIA, A. C. S.; PRACIANO, R. M. G.; DINIZ, J. A. R. A.; MOREIRA, A. de C.; PRAZERES JÚNIOR, F. R.; FREITAS, C. I. A.; BRAGA, J. F. V. ASSOCIATION OF NYSTATIN AND SODIUM BENZOATE IN THE TREATMENT OF MACRORHABIDOSE IN COCKATIEL IN NORTHEAST BRAZIL. Ciência Animal, [S. l.], v. 35, n. 2, p. 141–147, 2025. Disponível em: https://revistas.uece.br/index.php/cienciaanimal/article/view/15808. Acesso em: 5 dec. 2025.