Feline splenic myelolipoma
Keywords:
Neoplasm, Splenic myelolipoma, FelineAbstract
Myelolipomas are benign neoplasms of adipose cells that contain hematopoietic elements, considered infrequent and difficult to diagnose. The following paper reports a case of splenic myelolipoma diagnosed in a feline in the southern region of Rio Grande do Sul. The patient was referred for care at a veterinary clinic but died. Macroscopically, a nodule measuring 2.0 cm in diameter was observed in the spleen, with a cut surface that was lighter in color than the organ and soft in consistency. Histologically, there was proliferation of mature and well-differentiated adipose tissue, with cells of round to oval shapes, with small and peripheral nuclei, together with a large number of hematopoietic cells consisting of megakaryocytes, mature erythrocytes, in addition to macrophages, lymphocytes and plasma cells. These cellular components were also visualized in other organs, namely the pancreas, kidneys, liver and heart, characterizing the neoplasm. There are few descriptions of splenic myelolipoma in felines in the literature. In Brazil there is a description of this neoplasm in the spleen only in canines. Despite being a benign neoplasm, it should be considered in the differential diagnosis of pathologies that affect the lymphoid system.
References
ALVES, G.V.; GOLDRAICH, L.; RECK, L.L.; LONGHI, J.A; REMONT, T.A.P. Mielolipoma gigante - Relato de caso e revisão de literatura. Hospital das Clínicas de Porto Alegre, Porto Alegre, v.26, n.1, p.80-82, 2006.
BANDINELLI, M.B. Estudo retrospectivo de lesões em baço de cães esplenectomizados: 179 Casos. 2011. Pesquisa Veterinária Brasileira, v.31, n.8, p.697-701, 2011.
CAMPELLI, C.T.V.D.B.; ALVES, D.L.; LIMA, S.R.; BRAGA, G.; DALL`OLIO, A.J. Estudo retrospectivo de exames histopatológicos esplênicos na rotina laboratorial do hospital escola veterinário-UNIFAJ de 2015 a 2020. Veterinária e Zootecnia, Botucatu, v.28, s/n, p.1–7, 2021.
CARRILLO, J.D.; BOZA, S.; SOLER, M.; BELDA, E.; AGUT, A. What is your diagnosis? Journal of the American Veterinary Medical Association, v.240, n.4, p.375-376, 2012.
CASSARO, L.; DE ALMEIDA, N.Z.; LEMOS, V.Z.; COTA, J.M.; MOSCON, L.A.; DE BARROS, S.V.S.G.; SCHILD, A.L.; PERREIRA, C.M. Splenic myelolipoma in a dog. Ciência Rural, Santa Maria, v.51, n.4, p.1-4, 2021.
COSTA, S.R.P. Mielolipoma gigante de supra-renal com ruptura espontânea. BSBM Brasília Médica, v.45, n.2, p.144-147, 2008.
FRANÇA, S.A; ECCO, R; GUEDES, R.M.C. Mielolipoma adrenal bilateral em um cão. Ciência Rural, Santa Maria, v.38, n.5, p.1479-1482, 2008.
LATIMER, K.S., RAKICH, P.M. Subcutaneous and hepatic myelolipomas in four exotic birds. Veterinary Pathology, v.32, n.1, p.84-87, 1995.
LINDER, K.E. Tumors of the spleen. In: MEUTEN, D.J. Tumors in domestic animals. California, 5. ed. John Wiley & Sons Inc, 2017. p.317-318.
LOMBARD, L.S.; FORTNA, H.M.; GAMERA, F.M.; BRYNJOLFSSON, G. Myelolipomas of the liver in captive wild felidae. Pathologia Veterinaria, v.5, n.2, p.127-134, 1968.
MONTERO, F.; ALBIGER, N. A Comprehensive approach to adrenal incidentalomas. Arquivos Brasileiros de Endocrinologia & Metabologia, v.48, n.5, p. 583-589, 2004.
NAI, G.A.; AGUIAR, L.D.C.; GIMENEZ, V.R. Mielolipoma gigante bilateral da glândula adrenal. Jornal Brasileiro de Patologia e Medicina Laboratorial, v.43, n.4, p.265-268, 2007.
ROLPH, K.E.; VIDANA, B.; FIELD, E. Giant splenic myelolipoma in a cat with hyperthyroidism. Journal of Feline Medicine and Surgery Open Reports, v.8, n.2, p.1-6, 2022.
SATO, K.; UEDA, Y.; KATSUDA, S.; TSUCHIHARASU, K. Myelolipoma of the lung: a case report and brief review. Journal of Clinical Pathology, v.60, n.6, p.728–730,2007.
SILVA, J.G.D. Emprego da histopatologia no diagnóstico diferencial de lesões nodulares esplênicas em cães submetidos à esplenectomia, 2020. 26p. (Dissertação de Mestrado em Patologia Ambiental e Experimental). Universidade Paulista-UNIP, São Paulo, 2020.
SHEN, C.; HAN, Z.; CHE, G. A bilateral neoplasm in chest: a case report and literature review. BMC Surgery, v.14, n.42, p.1-6, 2014.
ZATTONI, D.; BALZAROTTI, R.; ROSSO, R. The management of bilateral myelolipoma: case report and review of the literature. International Journal of Surgery Case Reports, v.12, p.31–36, 2015.
ZENG, Y.; MA, Q.; LIN, L.; FU, P.; SHEN, Y.; LUO, Q.Y.; ZHAO, L.H.; MOU, J.H; XIAO, H.L. Giant myelolipoma in the spleen: a rare case report and literature review. International Journal of Surgical Pathology, v.24, n.2, p.177-180, 2015.
