Morphological changes in kidneys of seropositive dogs for visceral leishmaniasis
Keywords:
Leishmania, dogs, glomerulonephritisAbstract
Canine visceral leishmaniasis (LVC) is a severe chronic disease that affects dogs and the human being, causing lesions in several organs, for example, liver and kidneys. Abnormalities of renal function lead to an increasing concentration of urea, creatinine, and other non-protein nitrogen compounds in the bloodstream, resulting in azotemia. In this scientific article, 20 adult dogs from the Center for Zoonoses Control (CCZ) in the city of Fortaleza, Ceará, were positive to LVC by indirect immunofluorescence reaction (RIFI) and Enzyme Linked Immuno Sorbent Assay (ELISA). Blood and urine samples were collected from the animals for serum creatinine dosage and urinalysis, respectively. After euthanasia, both kidneys were removed and processed for conventional histopathological analysis. In the urinalysis, proteinuria, cylindrury and bacteriuria were observed. Histopathological analysis revealed a discreet interstitial fibrosis in 35% (7/20) of the samples, multifocal glomerulosclerosis and chronic lymphoplasmacytic interstitial nephritis in 20% (4/20) of the total kidneys evaluated. Such histopathological lesions and alterations in the sedimentation are compatible with what has been described in the literature for dogs with LVC. However, a higher percentage of dogs in stage I, according to International Renal Interest Society (IRIS), it demonstrated that histopathological changes were not followed by large changes in creatinine values Serum. The objective of the present paper was to study and characterize the main renal lesions through urinalysis and histopathology in dogs seropositive to Leishmania spp. and staging the chronic renal disease by serum creatinine.
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