HIPERPLASIA PROSTÁTICA BENIGNA EM CÃES
Keywords:
Dog, accessory sexual gland, prostatic diseaseAbstract
Benign Prostatic Hyperplasia (BPH) is a pathology originated from the prostate, the only accessory sexual gland in dogs, and its development occurs in older, uncastrated animals of unknown etiology. This literature review aims to discuss the clinical signs, forms of diagnosis and treatment this disease. Serum dihydrotestosterone is the main hormone that stimulates the growth of the canine prostate. The main clinical signs of this pathology involve weight loss, dyschezia, tenesmus, urinary incontinence, urethral secretion and hematuria. The diagnosis of canine prostate pathologies requires a thorough knowledge of anatomy and clinical signs, rectal palpation, ultrasonography and radiography, hematological analysis, biochemical profile, cytology of prostatic fluid, histopathological examination of prostate and the use of biomarkers, all help in the diagnosis of BPH. The most effective treatment is orchiectomy, but finasteride, delmadione acetate, osasterone or the application of Botulinum Toxin-A (TB-A) may also be used as treatment.
References
ALBOUY, M.; SANQUER, A.; MAYNARD, L.; EUN, H. M. Efficacies of osaterone and delmadinone in the treatment of benign prostatic hyperplasia in dogs. Veterinary Record, v.163, n.6, p.179-183, 2008.
ALONGE, S.; MELANDRI, M.; LEOCI, R.; LACALANDRA, G.M.; AIUDI, G. Canine prostate specific esterase (CPSE) as an useful biomarker in preventive screening programme of canine prostate: CPSE threshold value assessment and its correlation with ultrasonographic prostatic abnormalities in asymptomatic dogs. Reproduction in Domestic Animals, v.53, n.2, p.359-364, 2017.
ANGRIMANI, D.S.R.; SILVESTRINI, G.R.; BRITO, M.M.; ABREU, R.A.; ALMEIDA, L.L.; VANNUCHI, C.I. Effects of benign prostatic hyperplasia and finasteride therapy on prostatic blood flow in dogs. Theriogenology, v.114, p.103-108, 2018.
AQUINO-CORTEZ, A.; CORTEZ, A.A.; CARDOSO, R.C.S.; SILVA, L.D.M. Características físico-químicas do líquido prostático canino antes e após congelação. Revista Brasileira de Reprodução Animal, v.27, n.1, p.17-21, 2003.
AQUINO-CORTEZ, A.; SILVA, L. D. M., ARAÚJO, A. A., MENEZES, E. S. B., MOURA, A. A. Proteins of the canine seminal plasma. Ciência Rural, v.46, n.5, p.901-908, 2016.
AQUINO-CORTEZ, A.; PINHEIRO, B.Q.; SILVA, H.V.R.; LIMA, D.B.C.; SILVA, T.F.P.; SOUZA, M.B.; VIANA, D.A.; XAVIER JUNIOR, F.A.F.; EVANGELISTA, J.S.A.M.; BRANDÃO F.Z.; SILVA, L.D.M. Serum testosterone, sperm quality, cytological, physicochemical and biochemical characteristics of the prostatic fraction of dogs with prostatomegaly. Reproduction in Domestic Animals, v.52, n.6, p.998-1003, 2017.
ATALAN, G.; BARR, F.J.; HOLT, P.E. Comparison of ultrasonographic and radiographic measurements of canine prostate dimensions. Veterinary Radiology and Ultrasound, v.40, n.4, p.408-412, 1999.
AUMÜLLER, G.; STOFFT, E.; TUNN, U. Fine structure of the canine prostatic complex. Anatomy and Embryology, v.160, n.3, p.327-340, 1980.
BARSANTI, J.A.; FINCO, D.R. Canine prostatic diseases. The Veterinary clinics of North America. Small animal practice, v.16, n.3, p.587-599, 1986.
BECERIKLISOY, H.B; AY, S.S.; KAYA, D.; AGAOGLU, A.R.; KUÇUKASLAN, I.; AKSOY, O.A.; ERUNAL MARAL, N.; FINDIK, M.; ASLAN, S. Treatment of hypersexuality and benign prostatic hypertrophy with delmadinone acetate in intact male dogs. Turkish Journal of Veterinary and Animal Sciences, v.34, n.1, p.25-31, 2010.
BIGLIARDI, E.; FERRARI, L. Contrast-enhanced ultrasound of the normal canine prostate gland. Veterinary Radiology and Ultrasound, v.52, n.1, p.107-110, 2011.
BRANDÃO, C.V.S.; MANPRIM, M.; RANZANI, J.J.T.; MARINHO, L.F.L.P.; BORGES, A.G.; ZANINI, M.; ANTUNES, S.H.S.; BICUDO, A.L.C. Orquiectomia para a redução do volume porstático. Estudo experimental em cães. (Orchiectomy to reduce the prostatic size. Experimental study in dogs). Archives of Veterinary Science, v.11, n.2, p.7-9, 2006.
CHAPDELAINE, P.; DUBÉ, J.Y.; FRENETTE, G.; TREMBLAY, R.R. Identification and Preliminary of Arginine Protein Esterase Secreted by as the Dog Major Prostate in Plasma Molecular Characterization Seminal. Journal of andrology, v. 5, n. 3, p. 206–210, 1983.
DE SOUZA, M.B; SILVA, L.D.M.; MOXON, R.; RUSSO, M.; ENGLAND, G.C.W. Ultrasonography of the prostate gland and testes in dogs. In Practice, v.39, n.1, p.21-32, 2017.
ENGLAND, G.C.W.; ALLEN, W.E. An investigation into the origin of the first fraction of the canine ejaculate. Research in veterinary science, v.49, p.66-70, 1990.
ENGLAND, G.C.W.; ALLEN, W.E. Factors affecting the viability of canine spermatozoa II. Effects of seminal plasma and blood. Theriogenology, v.37, n.2, p.373-381, 1992.
FONSECA ALVES, C.E.; FALEIRO, M.B.R.; LAUFER AMORIM, R.; DE MOURA, V.M.B.D. Avaliação histológica da próstata de cães adultos sexualmente intactos. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v.62, n.3, p.596-602, 2010.
GADELHA, C.R.F.; VICENTE, W.R.R.; SILVA, L.D.M.; ALENCAR, A.A.; CAMPOS, A.C.N.; LIMA, T.S.; DIÓGENES, D. Mensuração ultra-sonográfica e física da próstata canina. Ciência Animal, v.18, n.2, p.51-56, 2008.
GOBELLO, C.; CASTEX, G.; CORRADA, Y. Serum and seminal markers in the diagnosis of disorders of the genital tract of the dog: a mini-review. Theriogenology, v.57, p.1285-1291, 2002.
GÜNZEL-APEL, A.R.; MÖHRKE, C.; NAUTRUP, C.P. Colour-coded and pulsed Doppler sonography of the canine testis. Epididymis and prostate gland: Physiological and pathological findings. Reproduction in Domestic Animals, v. 36, p. 236-240, 2001.
HOLST, B.S.; HOLMROOS, E.; FRILING, L.; HANAS, S.; LANGBORG, L.-M.; FRANKO, M.A.; HANSSON, K. The association between the serum concentration of canine prostate specific esterase (CPSE) and the size of the canine prostate. Theriogenology, v.93, p.33-39, 2017.
JIA, G.; BAUDENDISTEL, K.T.; VON TENGG-KOBLIGK, H.; HEVERHAGEN, J.T.; POLZER, H.; HENRY, H.; MCAULIFFE, M.J.; LEVINE, A.L; ROSOL, T.J.; KNOPP, M.V. Assessing Prostate Volume by Magnetic Resonance Imaging. Original Article, v.40, n.4, p.243-248, 2005.
JOHNSTON, S.D.; KAMOLPATANA, K.; ROOT-KUSTRITZ, M.V.; JOHNSTON, G.R. Prostatic disorders in the dog. Animal Reproduction Science, v.60-61, p.405-415, 2000.
KAWAKAMI, E.; AMEMIYA, E.; NAMIKAWA, K.; KASHIWAGI, C.; HORI, T.; TSUTSUI, T. High plasma estradiol-17β levels in dogs with benign prostatic hyperplasia and azoospermia. Journal of Veterinary Medical Science, v.63, n.4, p.407-412, 2000.
KRAFT, M.; BROWN, H.M.; LEROY, B.E. Cytology of the canine prostate. Irish Veterinarian Journal, v.61, n.5, p. 320-324, 2004.
KUSTRITZ, M.V.R. Collection of tissue and culture samples from the canine reproductive tract. Theriogenology, v.66, n.3, p.567-574, 2006.
KUSTRITZ, M.V.R.; KLAUSNER, J.S. Doenças prostáticas. In: ETTINGER, S.J.; FELDMAN, E.C. Tratado de Medicina Interna Veterinária - Doenças do Cão e do Gato, 2004. p.1777-1788.
LÉVY, X.; NIZAŃSKI, W.; VON HEIMENDAHL, A.; MIMOUNI, P. Diagnosis of Common Prostatic Conditions in Dogs: an Update. Reproduction in Domestic Animals, v.49, n.2, p.50-57, 2014.
LOWSETH, L.A.; GERLACH, F.; GILLETT, N.A; MUGGENBURG, B.A. Age-related changes in the prostate and testes of the beagle dog. Veterinary pathology, v.27, n.5, p.347-353, 1990.
MANTZIARAS, G.; ALONGE, S.; FAUSTINI, M.; LUVONI, G.C. Assessment of the age for a preventive ultrasonographic examination of the prostate in the dog. Theriogenology, v.100, p.114-119, 2017.
MASSERDOTTI, C. Architectural patterns in cytology: Correlation with histology. Veterinary Clinical Pathology, v.35, n.4, p.388-396, 2006.
MEMON, M.A. Common causes of male dog infertility. Theriogenology, v.68, n.3, p.322-328, 2007.
MOGIELNICKA-BRZOZOWSKA, M.; SLOWINSKA, M.; FRASER, L.; WYSOCKI, P.; STRZEZEK, R.; WASILEWSKA, K.; KORDAN, W. Identification and characterization of non-phosphorylcholine-binding and phosphorylcholine-binding proteins of canine seminal plasma. Annals of Animal Science, v.17, n.3, p.771–786, 2017.
MOSTACHIO, G.Q.; APPARÍCIO, M.; MOTHEO, T.F.; ALVES, A.E.; VICENTE, W.R.R. Administração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cão. Ciência Rural, v.45, n.9, p.1654-1659, 2015.
MUKARATIRWA, S.; CHITURA, T. Canine subclinical prostatic disease: histological prevalence and validity of digital rectal examination as a screening test. Journal of the South African Veterinary Association, v.78, n.2, p.66-68, 2007.
NEWELL, S.M.; NEUWIRTH, L.; GINN, P.E. ROBERTS, G.D.; PRIME, L.S.; HARRISON, J.M. Doppler ultrasound of the prostate in normal dogs and in dogs with chronic lymphocytic-lymphoplasmasmacytic prostatitis. Veterinary Radiology and Ultrasound, v.39, n.4, p.332-336, 1998.
PINHEIRO, D.; MACHADO, J.; VIEGAS, C.; BAPTISTA, C.; BASTOS, E.; MAGALHÃES J.; PIRES, M.A.; CARDOSO, L.; MARTINS-BESSA, A. Evaluation of biomarker canine-prostate specific arginine esterase (CPSE) for the diagnosis of benign prostatic hyperplasia. BMC veterinary research, v.13, n.1, p.76, 2017.
POLISCA, A.; TROISI, A.; FONTAINE, E.; MENCHETTI, L.; FONTBONNE, A. A retrospective study of canine prostatic diseases from 2002 to 2009 at the Alfort Veterinary College in France. Theriogenology, v.85, n.5, p.835-840, 2016.
POWE, J.R.; CANFIELD, P.J.; MARTIN, P.A. Evaluation of the cytologic diagnosis of canine prostatic disorders. American Society for Veterinary Clinical Pathology, v.33, n.3, p.150-154, 2004.
RUSSO, M.; VIGNOLI, M.; CATONE, G.; ROSSI, F.; ATTANASI, G.; ENGLAND, G.C.W. Prostatic perfusion in the dog using contrast-enhanced Doppler ultrasound. Reproduction in Domestic Animal, v.44, n.2, p.334-335, 2009.
RUSSO, M.; VIGNOLI, M.; ENGLAND, G.C.W. B-mode and contrast-enhanced ultrasonographic findings in canine prostatic disorders. Reproduction in Domestic Animals, v.47, n.6, p.238-242, 2012.
SHIDAIFAT, F. Age-dependent expression of 5α-reductase and androgen receptors mRNA by the canine prostate. Physiological research, v.58, n.1, p.155-158, 2009.
SHIMOMURA, J.Z.; EUGÊNIO, F.R.; LUVIZOTTO, M.C.R.; PERRI, S.H.V. Hiperplasia prostática benigna no cão: comparação entre métodos diagnósticos. Veterinária e zootecnia, v.16, n.1, p.117-126, 2009.
SIRINARUMITR, K.; JOHNSTON, S.D.; KUSTRITZ, M.V.R.; JOHNSTON, G.R.; SARKAR, D.K.; MEMOM, M.A. Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy. Journal of the American Veterinary Medical Association, v.218, n.8, p.1275-1280, 2001.
SMITH, J. Canine prostatic disease: a review of anatomy, pathology, diagnosis, and treatment. Theriogenology, v.70, n.3, p.375-383, 2008.
VIGNOLI, M.; RUSSO, M.; CATONE, G.; ROSSI, F.; ATTANASI, G.; TERRAGNI, R.; SAUNDERS, J.H.; ENGLAND, G.C.W. Assessment of vascular perfusion kinetics using contrast-enhanced ultrasound for the diagnosis of prostatic disease in dogs. Reproduction in domestic animals, v.46, n.2, p.209-213, 2011.
WOLF, K.; KAYACELEBI, H.; URHAUSEN, C.; PIECHOTTA, M.; MISCHKE, R.; KRAMER, S.; EINSPANIER, A.; OEI, C.; GUNZEL-APEL, A. Testicular Steroids, Prolactin, Relaxin and Prostate Gland Markers in Peripheral Blood and Seminal Plasma of Normal Dogs and Dogs with Prostatic Hyperplasia. Reproduction in Domestic Animals, v.47, n.6, p.243-246, 2012.
ZAMBELLI, D.; CUNTO, M.; GENTILINI, F. Validation of a model to develop a symptom index for benign prostatic hyperplasia in dogs. Reproduction in Domestic Animals, v.47, n.6, p.229-231, 2012.
ZINKL, J.G. The Male Reproductive Tract: Prostate, Testes, and Semen. In: COWELL, R.L.; TYLER, R.D.; MEINKOTH, J.H.; DENICOLA, D.B. Diagnostic cytology and hematology of the dog and cat, 2008. p.369-377.