CRYOSURGERY USING DIMETHYL ETHER IN THE TREATMENT OF PIGMENTARY KERATITIS IN PUG DOGS

Autor/innen

  • Médico Veterinário Autônomo, Lages/SC
  • Veterinária Autônoma, Porto Alegre/RS
  • Veterinária Autônoma, Porto Alegre/RS
  • Veterinária autônoma, Vitória/ES
  • Oftalmo Vet Colombia/Bogotá
  • Universidade Estadual Paulista “Julio de Mesquita Filho"

Schlagworte:

Surgery, Eye, Ophthalmology, Canine, Cryosurgery

Abstract

Corneal pigmentation and vascularization eventually result in blindness in dogs. Pigmentary keratitis describes a relatively common presentation comprising the deposition of melanin in the cornea and conjunctival surface associated with chronic inflammation. Cryosurgery is indicated as a treatment for pigmentary keratitis in dogs. Due to melanocytes sensitivity to cold, cryosurgery is a viable treatment for severe refractory corneal pigmentation. The aim of this work was to evaluate the use of dimethyl ether in the treatment of pigmentary keratitis in 14 eyes of seven Pug dogs. Follow-up occurred after 30 days in four animals and six months in three animals. In all treated animals, there was a reduction in corneal pigmentation. Cryosurgery causes intracellular and extracellular ice crystal formation and other mechanisms that result in rupture and death of the melanocytes. The technique used was easy to perform, has a low cryogen cost and has few undesirable or serious side effects. However, after 30 days repigmentation occured in treated patients. Cryosurgery shows good results in the first four weeks, but partial recurrence occurred in all cases.

Literaturhinweise

AHN, J.; JEONG, M.; PARK, Y.; LEE, Y.; LEE, E.; KIM, S.; LEE, I.; SEO, K. Comparison of systemic atracurium, retrobulbar lidocaine, and sub‐Tenon's lidocaine injections in akinesia and mydriasis in dogs. Veterinary ophthalmology, v.16, n.6, p.440-445, 2013.

ALLGOEWER, I.; HOECHT, S. Radiotherapy for canine chronic superficial keratitis using soft X-rays (15 kV). Veterinary Ophthalmology, v.13, n.1, p.20-25, 2010.

ALLGOEWER, I.; SAHR, S.; NEUMANN, K. Preliminary results of the evaluation of the long-term effect of different therapies for pigmentary keratitis of the pug. Veterinary Ophthalmology, v.19, n.6, p.21-43, 2016.

ANOOP, S.; DEVANAND, C.B.; SYAM, K.V.; MARTIN, K.D.; AJITHKUMAR, S.; GLEEJA, L.; GHOSH, K.N. Indian Journal of Veterinary Research, v.24, n.1, p.31-33, 2015.

APPELBOAM, H. Pug appeal: brachycephalic ocular health. Companion Animal, v.21, n.1, p.29-36, 2016.

AZOULAY, T. Adjunctive cryotherapy for pigmentary keratitis in dogs: a study of 16 corneas. Veterinary Ophthalmology, v.17, n.4, p.241-249, 2014.

BARACHETTI, L.; GIUDICE, C.; CESCON, M.; MORTELLARO, C.M.; FERRARI, R.; RAMPAZZO, A. The effects of soft cryotherapy on conjunctiva and cornea in isolated pig eyes and comparison with standard liquid nitrogen: A pilot ex vivo study. Veterinary Ophthalmology, v.23, n.3, p.544-551, 2020.

CHEN, Y.; YANG, W.; GAO, M.; BELIN, M.W.; YU, H.; YU, J. Experimental study on cryotherapy for fungal corneal ulcer. BMC Ophthalmology, v.15, n.1, p.1-9, 2015.

COSTA, J.; STEINMETZ, A.; DELGADO, E. Clinical signs of brachycephalic ocular syndrome in 93 dogs. Irish Veterinary Journal, v.74, n.1, p.1-8, 2021.

FEATHERSTONE, H.J.; RENWICK, P.; HEINRICH, C.L.; MANNING, S. Efficacy of lamellar resection, cryotherapy, and adjunctive grafting for the treatment of canine limbal melanoma. Veterinary Ophthalmology, v.12, n.1, p.65-72, 2009.

FRAUNFELDER, F.W.; ALLOJU, S.; PATEL, M. Liquid Nitrogen Cryotherapy Treatment of Herpes Simplex Epithelial Keratitis. Missouri Medicine, v.114, n.2, p.129-132, 2017.

GRADILONE, L.; ARTILES, S.; MENDOZA, E.; MORALES-FARINA, I. Clinical evaluation of the effect of diamond burr debridement in pigmentary keratitis in the dog: two case reports. Veterinary Ophthalmology, v.15, n.6, p.1-2, 2012.

HAGER, T.; HASENFUS, A.; STACHON, T.; SEITZ, B.; SZENTMÁRY, N. Crosslinking and corneal cryotherapy in acanthamoeba keratitis - a histological study. Graefe's Archive for Clinical and Experimental Ophthalmology, v.254, n.1, p.149-153, 2016.

HOLMBERG, D.L.; SCHEIFER, H.B.; PARENT, J. The cryosurgical treatment of pigmentary keratitis in dogs an experimental and clinical study. Veterinary Surgery, v.15, n.1, p.1-4, 1986.

KRECNY, M.; TICHY, A.; RUSHTON, J.; NELL, B.A. A retrospective survey of ocular abnormalities in pugs: 130 cases. Journal of Small Animal Practice, v.56, n.2, p.96-102, 2015.

KUMAR, T., PUNIA, M., AGNIHOTRI, D., SINDHU, N., JAIN, V.K. Incidence of Ophthalmic Affections in Dogs–A Short Study. International Journal of Current Microbiology Applied Science, v.7, n.9, p.1560-1565, 2018.

LABELLE, A.L.; DRESSER, C.B.; HAMOR, R.E.; ALLENDER, M.C.; DISNEY, J.L. Characteristics of, prevalence of, and risk factors for corneal pigmentation (pigmentary keratopathy) in Pugs. Journal of the American Veterinary Medical Association, v.243, n.5, p.667-674, 2013.

MAINI, S.; EVERSON, R.; DAWSON, C.; CHANG, Y.M.; HARTLEY, C.; SANCHEZ, R.F. Pigmentary keratitis in pugs in the United Kingdom: prevalence and associated features. BMC Veterinary Research, v.15, n.1, p.1-11, 2019.

MERIDETH, R.E.; GELATT, K.N. Cryotherapy in veterinary ophthalmology. The Veterinary Clinics of North America. Small Animal Practice, v.10, n.4, p.837–846, 1980.

OELLERS, P.; KARP, C. L.; SHAH, R. R.; WINNICK, M.; MATTHEWS, J.; DUBOVY, S. Conjunctival keratoacanthoma. British Journal of Ophthalmology, v.98, n.2, p.275-276, 2014.

QURESHI, B.; MAHAJAN, S.K.; DEVI, N.U.; MOHINDROO, J.; PATHAK, D. Evaluation of superficial keratectomy for the management of pigmentary keratitis in Pug dogs. International Journal of Current Microbiology and Applied Sciences, v.9, n.10, p.3592-3598, 2020.

RICKARDS, D.A. Cryosurgery in small animal ophthalmology. The Veterinary Clinics of North America. Small Animal Practice, v.10, n.2, p.471-480, 1980.

STANLEY, R.G. Superficial stromal keratitis in the dog. Australian Veterinary Journal, v.65, n.10, p.321-323, 1988.

TEHRANI, S.; FRAUNFELDER, F.W. Cryotherapy in ophthalmology. Open Journal of Ophthalmology, v.3, n.4, p.103-117, 2013.

VALLONE, L.V.; ENDERS, A.M.; MOHAMMED, H.O.; LEDBETTER, E.C. In vivo confocal microscopy of brachycephalic dogs with and without superficial corneal pigment. Veterinary Ophthalmology, v.20, n.4, p.294-303, 2017.

WEB FRAUNFELDER, F. Liquid nitrogen cryotherapy for surface eye disease (An AOS thesis). Transactions of the American Ophthalmological Society, v.106, n.1, p.301-324, 2008.

YI, N.Y.; PARK, S.A.; JEONG, M.B.; KIM, M.S.; LIM, J.H.; NAM, T.C.; SEO, K. Medial canthoplasty for epiphora in dogs: a retrospective study of 23 cases. Journal of the American Animal Hospital Association, v.42, n.6, p.435-439, 2006.

Veröffentlicht

2022-11-17

Zitationsvorschlag

EDUARDO; PAULA STIEVEN; MARIA CRISTINA CALDART DE; GISELE PEREIRA; TATIANA; RAFAEL KRETZER. CRYOSURGERY USING DIMETHYL ETHER IN THE TREATMENT OF PIGMENTARY KERATITIS IN PUG DOGS. Ciência Animal, [S. l.], v. 32, n. 3, p. 200–208, 2022. Disponível em: https://revistas.uece.br/index.php/cienciaanimal/article/view/9516. Acesso em: 10 mai. 2024.