A ESPERMATOGÊNESE
Schlagworte:
Espermatogônia, Gametogênese, Reprodução, EspermatozoideAbstract
A espermatogênese é o processo fisiológico de formação dos gametas masculinos em que as células de linhagem germinativa, denominadas de espermátides, células haplóides originadas das espermatogônias através do processo de divisão celular e que possuem a porção específica de DNA para fins reprodutivos, passam por etapas de diferenciação celular, desde sua organização estrutural, morfológica e bioquímica, dando origem assim aos espermatozoides que serão liberados no lúmen dos túbulos seminíferos, com posterior embriogênese. As espermátides são células arredondadas, de núcleo central e envolto de citoplasma, em que durante o processo de maturação, ocorre a reorganização das organelas presentes nesta célula, moldando-a para uma forma alongada. Há também o desenvolvimento do acrossoma, migração das mitocôndrias para a porção caudal do espermatozoide para geração de energia que concomitantemente auxiliará na movimentação da célula juntamente com uma cauda, também desenvolvida, e que é de extrema importância no quesito reprodutivo. Desta forma, o objetivo desta revisão de literatura foi exemplificar como ocorre as etapas da espermatogênese de uma forma objetiva, cooperando para o entendimento desta fase da gametogênese que está associada a resultados reprodutivos.
Literaturhinweise
ALVES, M.G.; RATO, L.P.; CARVALHO, R.A.; MOREIRA, P.I. Hormonal control of Sertoli cell metabolism regulates spermatogenesis. Cellular and Molecular Life Sciences, v.70, n.5, p.777-793, 2013.
AMANN, R.P.; SEIDEL, G.E.Jr.; MORTIMER, R.G. Fertilizing potential in vitro of semen from young beef bulls containing a high or low percentage of sperm wit proximal droplet. Theriogenology, v.54, n.9, p.1499-1515, 2000.
ANGRIMANI, D.S.R.; LOSANO, D.S.R.; LUCIO, C.F.; VEIGA, G.A.L.; LANDIM, F.C.; NICHI, M.; VANNUCCHI, C.I. Cytoplasmic droplet acting as a mitochondrial modulator during sperm maturation in dogs. Animal Reproduction Science, v.181, n.1, p.50-56, 2017.
APONTE, P.M.; ROOIJ, D.G.; BASTIDAS, P. Testicular development in Brahman bulls. Theriogenology, v.64, n.6, p.1440-1455, 2005.
ASSIS NETO, A.C.; CARVALHO, M.A.M; MELO, M.I.V.; MIGLINO, M.A.; OLIVEIRA, M.F.; MARIANA, A.N.B. Fases do desenvolvimento e diferenciação testicular em cutias (Dasyprocta aguti) criadas em cativeiros Braz. Journal of Veterinary Research and Animal Science, v.40, supl.1, p.71-79, 2003.
AU, C.E.; HERMO, L.; BYRNE, E.; SMIRLE, J.; FAZEL, A.; KEARNEY, R.E.; SMITH, C.E.; VALI, H.; FERNANDEZ-RODRIGUEZ, J.; SIMON, P.H.; MANDATO, C.; NILSSON, T.; BERGERON, J.J. Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm. Open Biology, v.5, p.1-18, 2015. Disponível em: https://www. researchgate.net/publication/281341834_Compartmentalization_of_membrane_trafficking_glucose _transport_glycolysis_actin_tubulin_and_the_proteasome_in_the_cytoplasmic_droplet HERMES_body_of_epididymal_sperm. Acessado em: 07 05. 2022.
AULER, P.A.; MOREIRA, G.H.F.A.; HOGG, C.O.; ASHWORTH, C.J.; BORTOLOZZO, F.P.; CHIARINI-GARCIA, H.; ALMEIDA, F.R.C.L. Testicular parameters and spermatogenesis indiferent birthweight boars. Reproduction Fertility and Development, v.29, n.9, p.1720-1728, 2017.
AVELAR, G.F.; OLIVEIRA, C.F.A.; SOARES, J.M.; SILVA, I.J.; DOBRINSKI, I.; HESS, R.A.; FRANÇA, L.R. Post-natal somatic cell proliferation and seminiferous tubule maturation in pigs: A non-random event. Theriogenology, v.74, n.1, p.11-23, 2010.
BALINSKY, J. Reflections on respecialization. The Clinical Psychologist, v.36, n.3, p.67–68, 1983.
BERNDTSON, W.E.; JONES, L.S. Relationship of intratesticular testosterone content of stallions to age, spermatogenesis, Sertoli cell distribution and germ cell-Sertoli cell ratios. Journal of Reproduction and Fertility v.85, n.2, p.511-8, 1989.
CARREIRA, J.T.; MINGOTI, G.Z.; RODRIGUES, L.H.; SILVA, C.; PERRI, S.H.V.; KOIVISTO, M.B. Impact of proximal cytoplazmic droplets on quality traits and in-vitro embryo production efficiency of cryopreserved bull spermatozoa. Acta Veterinaria Scandinavica, v.54, n.1, p.1-7, 2012.
CASTRO, A.C.S.; BERNDTSON, W.E.; CARDOSO, F.M. Cinética e quantificação da espermatogênese: bases morfológicas e suas aplicações em estudos da reprodução de mamíferos. Revista Brasileira de Reprodução Animal, v.21, n.1, p.25-34, 2002.
CHENOWETH, P.J. Genetic Sperm Defects. Theriogenology, v.64, n.3, p.457-468, 2005
CHOCU, S.; CALVEL, P.; ROLLAND, A.D.; PINEAU, C. Spermatogenesis in mammals:proteomic insights. Systems Biology in Reproductive Medicine, v.58, n.4, p.179-190, 2012.
COOPER, T.G. Cytoplasmic droplets: The good, the bad or just confusing? Human Reproduction, v.20, n.1, p.9-11, 2005.
COOPER, T.G. The epididymis, cytoplasmic droplets and male fertility. Asian Journal of Andrology, v.13, n.1, p.130-138, 2011.
COUROT, M.; de RIVIERS, M.T.H.; ORTAVANT, R. Spermatogenesis. In: JOHNSON, A.D.; GOMES W.R.; VANDEMARK, N.L. (Eds.) The testis. 1. ed. New York and London: Academic Press, v.1, cap.6, 1970. p.339-432.
COLVILLE, T.P. Anatomia e Fisiologia Clínica para Medicina Veterinária. 2. ed., São Paulo: Elsevier, 2010.
COSTA, D.S.; FARIA, F.J.; FERNANDES, C.A.; SILVA, J.C.B.; AUHAREK, S.A. Testis morphometry and kinetics of spermatogesis in the feral pig (Sus scrofa). Animal Reproduction Science, v.142, n.1/2, p.63-70, 2013.
CUNNINGHAM, J.C. Tratado de Fisiologia Veterinária. 5. ed. Revisada e atualizada. Rio de Janeiro: Elsevier Editora Ltda., 2014.
CURTIS, S.K.; AMANN, R.P. Testicular development and establishment of spermatogenesis in Holstein bulls. Journal of Animal Science, v.53, n.6, p.1645-1657, 1981.
DACHEUX, J.L.; DACHEUX, F. New insights into epididymal function in relation to sperm maturation. Reproduction, v.147, n.2, p.27-42, 2014.
DADOUNE, J; DEMOULIN, A. Structure and functions of testis. In: THIBAULT, C.; LEVASSEUR, M.C.; HUNTER, R.H.F. Reproduction in mammals and man. 1. ed., Paris: Ellipses, cap.13, 1993. p.227-255.
DUKES, H.H. Fisiologia dos Animais Domésticos. 13. ed. Revisada e atualizada. Rio de Janeiro: Guanabara Koogan, 2017.
EVANS, A.C.O.; PIERSON, R.A.; GARCIA, A.; MCDOUGALL, L.M.; HRUDKA, F.; RAWLINGS, N.C. Changes in circulating hormone concentrations, testes histology and testes ultrasonography during sexual maturation in beef bulls. Theriogenology, v.46, n.2, p.345-347, 1996.
FAWCETT, D.W. Ultrastructure and function of the Sertoli cell. 1. ed. Washington, D.C., American Physiological Society, 1975.
FLOWERS, W.L. Genetic and phenotypic variation in reproductive traits of AI boars. Theriogenology, v.70, n.8, p.1297-1303, 2008.
FRANÇA, L.R.; SILVA, V.A.Jr.; CHIARINI-GARCIA, H.; GARCIA, S.K.; DEBELJUK, L. Cell proliferation and hormonal changes during post development of the testis in the pig. Biological Reproduction, v.63, n.6, p.1629-1636, 2000.
FRANÇA, L.R.; AVELAR, G.F.; ALMEIDA, F.F.L. Spermatogenesis and sperm transit throughthe epididymis in mammals with emphasis on pigs. Theriogenology, v.63, n.2, p.300-318, 2005.
GADELLA, B.M.; LUNA, C.C. Cell biology and functional dynamics of the mammalian sperm surface. Theriogenology, v.81, n.1, p.74-84, 2014.
GALUPPO, A.G.S. Spermatogonial stem cells as a therapeutic alternative for fertility preservation of prepubertal boys. Einstein (São Paulo), v.13, n.4, p.637-639, 2015.
GIBB, Z.; AITKEN, R.J. The impacto of sperm metabolismo during in vitro storage: the stallion as a model. Biomed Research International, v.16, p.1-8, 2016. Disponível em: https://downloads.hindawi.com/journals/bmri/2016/9380609.pdf?_gl=1*16mjf10*_ga*MTgxNjk3OTMxNy4xNjk4ODQzNTUy*_ga_NF5QFMJT5V*MTY5ODg0MzU1Mi4xLjAuMTY5ODg0MzU1Mi42MC4wLjA.&_ga=2.83982681.1555909459.1698843552-1816979317.169 8843552. Acessado em: 23 03. 2022.
HAFEZ, E.S.E.; HAFEZ, B. Reprodução Animal. 7. ed., Manole, São Paulo. cap.7, 2004. p.97-107.
HERMO, L.; PELLETIER, R.M.; CYR, D.G.; SMITH, C.E. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Microscopy Research and Technique, v.73, n.4, p.320-363, 2010.
HESS, R.A.; BUNICK, D.; BAHR, J. Estrogen, its receptors and function in the male reproductive tract – review. Molecular Cells Endocrinology, v.178, n.1/2, p.29-38, 2001a.
HESS, R.A.; ZHOU, Q; NIE, R.; OLIVEIRA, C.; CHO, H.; NAKAIA, M.; CARNES, K. Estrogens and epididymal function. Reproduction Fertility and Development, v.13, n.4, p.273-83, 2001b.
HORDER, T.J. The organizer concept and modern embryology: Anglo-American perspectives. The International Journal of Developmental Biology, v.45, n.1, p.97-132, 2001.
HOLSTEIN, A.F.; SCHULZE, W.; DAVIDOFF, M. Understanding spermatogenesis is a prerequisite for treatment. Reproductive Biology and Endocrinology, v.1, p.1-16, 2003.
HULEIHEL, M; LUNENFELD, E. Regulation of spermatogenesis by paracrine/autocrine testicular factors. Asian Journal of Andrology, v.6, n.3, p.259-268, 2004.
JOHNSON, L.A. Sexing mammalian sperm for production of offspring: the state-of-the-art. Animal Reproduction Science, v.60/61, p.93-107, 2000.
JOHNSON, L.; VARNER, D.D.; THOMPSON JR., D.L. Effect of age and season on the establishment of spermatogenesis in the horse. Journal of Reproduction and Fertility., v.44, supl. 1, p.87-97, 1991.
JUNQUEIRA, L.C.; CARNEIRO, J. Histologia Básica. 12. ed., Grupo GEN. Editora Guanabara Koogan, Rio de Janeiro/RJ, 2013.
KRETSER, D.M.; LOVELAND, K.L.; MEINHARDT, A.; SIMORANGKIR, D; WREFORD, N. Spermatogenesis. Human Reproduction, v.13, supl.1, p.1-8, 1998.
KUSTER, C.E.; HESS, R.A.; ALTHOUSE, G.C: Immunofluorescence reveals ubiquitination of retained distal cytoplasmic droplets on ejaculated porcine spermatozoa. Journal of Andrology, v.25, n.3, p.340-347, 2004.
LEJEUNE, H.; HABERT, R.; SAEZ, J.M. Origin, proliferation and differentiation of Leydig cells. Journal of Molecular Endocrinology, v.20, n.1, p.1–25, 1998.
LIN, Y.; CHENG, X.; SUTOVSKY, P.; WU, D.; CHE, L.Q.; FANG, Z.F.; XU, S.Y.; REN, B.; DONG, H.J. Effect of intra-uterine growth restriction on long-term fertilityin boars. Reproductin, Fertility and Development, v.29, n.2, p.374-382, 2017.
LIU, P.Y.; HANDELSMAN, D.J. The present and the future state of hormonal treatment for male infertility. Human Reproduction Update, v.9, n.1, p.9-23, 2003.
LOVE, C.C. Stallion semen evaluation and interpretation.Proceedings Society for Theriogenology, American College of Theriogenologists, v.57, n.1, p.93-102, 2002.
LOVE, C.C. Sperm quality assays: How good are they? The horse perspective. Animal Reproduction Science, v.194, p.63-70, 2018.
MARAN, R.R. Thyreoid hormones: their role in testicular steroidogenesis. Archives of Andrology, v.49, n.5, p.375-388, 2003.
MARINA S. Avances en conocimiento la espermatogénesis. Revista Iberoamericana de Fertilidade, v.20, n.4, p.213-225, 2003.
MERTON, H. Studies on reproduction in the albino mouse. II. Contributions on the maturation of the sperm cells. Merton H. Studies on reproduction in the albino mouse. II. Contributions on the maturation of the sperm cells. Proceeding of the Royal Society: Biological Sciences, v.59, p.145-152, 1939.
MIDDENDORFF, R.; MÜLLER, D.; WICHERS, S.; HOLSTEIN, A.F.; DAVIDOFF, M.S. Evidence for production and functional activity of nitric oxide in seminiferous tubules and blli vessels of the human testis. Journal of Clinical and Endocrinology Metabolism, v.82, n.12, p.4154-4161, 1997.
MONTANARI, T. Embriologia: texto, atlas e roteiro de aulas práticas. 2. ed., P. Alegre, Tatiana, 2019.
MOORE, K.; LOVERCAMP, K.; FENG, D.; ANTELMAN, J.; SUTOVSKY, M.; MANANDHAR, G.; VAN LEYEN, K.; SAFRANSKI, T.; SUTOVSKY, P. Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice. Cell Tissue Research, v.340, n.3, p.569-581, 2010.
MUKAI, C.; OKUNO, M. Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagelar movement. Biology of Reproduction, v.71, n.2, p.540-547, 2004.
NETO, F.T.; BACH, P.V.; NAJARI, B.B.; LI, P.LS.; GOLDSTEIN, M. Spermatogenesis in humans and its affecting factors. Seminal Cells Development and Biology, v.59, p.10-26, 2016.j
PETERSEN, C.; SÖDER, O. The Sertoli Cell – A Hormonal Target and ‘Super’ Nurse for Germ cells That Determines Testicular Size. Hormone Research, v.66, n.4, p.153-161, 2006.
RATO, L.; ALVES, M. G.; SOCORRO, S.; DUARTE, A.I.; CAVACO, J.E.; OLIVEIRA, P.F. Metabolic regulation is important for spermatogenesis. Nature Reviews Urology, v.9, n.6, p.330-338, 2012.
RENGAN, A.K.; AGARWAL, A.; VAN DER LINDE, M.; DU PLESSIS, S.S. An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet. Reproductive Biology and Endocrinology, v.10, p.92, 2012. Disponível em: https://rbej.biomedcentral.com/articles/10.1186/1477-7827-10-92. Acessado em: 24 04. 2022.
RUSSELL, L.D; FRANÇA, L.R. Building a testis. Tissue and Cell. v.27, n.2, p.129-147, 1995.
RUWANPURA, S.M.; MCLACHLAN, R.I.; MEACHEM, S.J. Hormonal regulation of male germ cell development. Journal of Endocrinology, v.205, n.2, p.117-131, 2010.
SCHLATT, S.; EHMCKE, J. Regulation of spermatogenesis: na evolutionary biologist’s perspective. Seminal Cells Development and Biology, v.29, p.2-16, 2014.
SENGER, P.L. Pathways to pregnancy and parturition. Animal Reproduction Science, v.89, n.1/4, p.93-103, 2003.
SMITH, L.B.; WALKER, W.H. The regulation of spermatogenesis by androgens. Seminal Cells Development Biology, v.30, p.2-13, 2014.
SOARES, C.M.T.; MACHADO-NEVES, M. O papel da gota citoplasmática na funcionalidade de espermatozoides em mamíferos: uma revisão atualizada. Revista Brasileira de Reprodução Animal, v.44, n.3, p.83-88, 2020.
STAUB, C.; JOHNSON, L. Review: Spermatogenesis in the bull. Animal, v.12, supl. 1, p.27-35, 2018.
WU, H.; HAUSER, R.; KRAWETZ S.A.; PILSNER, J.R. Environmental susceptibility of the sperm epigenome during windows male germ cell development. Current Environm Health Reports, v.2, n.4, p.356-366, 2015.
YUAN, S.; ZHENG, H.; ZHENG, Z.; YAN, W. Proteomic analyses reveal a role of cytoplasmic droplets as na energy source during epididymal sperm maturation. PLOS ONE, v.8, p.77466, 2013.
XU, H.; YUAN, S.Q.; ZHENG, Z.H.; YAN, W. The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis. Asian Journal of Andrology, v.15, n.6, p.799-805, 2013.
ZIERI, R.; TABOGA, S.R.; OLIVEIRA, C.D. Espermiogênese em Eupemphix nattereri (Anura, Leiuperidae): aspectos ultra-estruturais. Iheringia série Zoologia, v.98, n.2, p.193-199, 2008.