Publicado 2024-12-30
Palavras-chave
- Proteína beta amilóide,
- neurofunção anima,
- geriatria felina
Como Citar

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Resumo
O envelhecimento pode ser definido como um processo de declínio progressivo nas funções fisiológicas de organismos vivos, sendo este associado à passagem do tempo e influenciado por fatores genéticos, ambientais e nutricionais. A Síndrome da Disfunção Cognitiva Felina (SDCF) é uma patologia neurodegenerativa relacionada a idade que causa a degeneração neuronal e a deterioração das sinapses, sendo semelhante a Doença de Alzheimer (DA) em humanos. A SDCF é caracterizada pela manifestação de alterações comportamentais, de modo especial
a vocalização, além de alterações relacionadas ao aprendizado e memória, bem como diminuição no nível de consciência (resposta a estímulos) e confusão. O diagnóstico definitivo para a SDCF consiste na exclusão de outras
possíveis doenças, além do exame clínico, físico, neurológico e testes laboratoriais/diagnósticos e a aplicação de um questionário de triagem cognitiva, para que doenças semelhantes sejam descartadas. Atualmente não existe cura para tal enfermidade, sendo o tratamento paliativo indicado para retardar o progresso da doença, através da suplementação vitamínica, terapia farmacológica, terapias dietéticas e de enriquecimento ambiental. Algumas semelhanças entre a SDCF e a DA podem ser encontradas incluindo a presença da proteína beta-amiloide e da proteína tau hiperfosforilada, sendo estas apontadas como possíveis desencadeadoras de tais doenças. Dessa forma, mediante a escassez de trabalhos científicos sobre a disfunção cognitiva em animais de companhia, sobretudo nos felinos domésticos, objetivou-se com o presente trabalho realizar uma revisão de literatura sobre a disfunção cognitiva em felinos domésticos, abordando desde aspectos etiológicos até seu tratamento.
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Referências
- AZKONA, G.; GARCÍA-BELENGUER, S.; CHACÓN, G.; ROSADO, B.; LEÓN, M.;
- PALACIO, J. Prevalence and risk factors of behavioural changes associated with age‐related cognitive impairment in geriatric dogs. Journal of Small Animal Practice, v.50, n.2, p.87-91,2009.
- BELLOWS, J.; CENTER, S.; DARISTOTLE, L.; ESTRADA, A.H.; FLICKINGER, E.A.;
- HORWITZ, D.F.; LASCELLES, B.D.X.; LEPINE, A.; PEREA, S.; SCHERK, M.;
- SHOVELLER, A.K. Aging in cats: Common physical and functional changes. Journal of Feline Medicine and Surgery, v.18, n.7, p.533-550, 2016a.
- BELLOWS, J.; CENTER, S.; DARISTOTLE, L.; ESTRADA, A.H.; FLICKINGER, E.A.;
- HORWITZ, D.F.; LASCELLES, B.D.X.; LEPINE, A.; PEREA, S.; SCHERK, M.;
- SHOVELLER, A.K. Evaluating aging in cats: How to determine what is healthy and what is disease. Journal of Feline Medicine and Surgery, v.18, n.7, p.551-570, 2016b.
- BRELLOU, G.; VLEMMAS, I.; LEKKAS, S.; PAPAIOANNOU, N. Immunohistochemical
- investigation of amyloid ß-protein (Aß) in the brain of aged cats. Histology and
- histopathology, 2005. Disponível em: http://hdl.handle.net/10201/22529. Acesso em: 02 fev. 2024.
- CAMPBELL, S.; TRETTIEN, A.; KOZAN, B. A noncomparative open-label study evaluating
- the effect of selegiline hydrochloride ina clinical setting. Veterinary Therapeutics, v.2, n.1, p,24-39, 2001.
- CASTILLO, C.; HERNÁNDEZ, J. the role of oxidative stress in the development of cognitive dysfunction syndrome in cats. Importance of antioxidant prevention and therapy. SOJ Veterinary Sciences, v.1, n.2, p.1-12, 2015.
- CERNA, P.; GARDINER, H.; SORDO, L.; TORNQVIST‐JOHNSEN, C.; GUNN‐MOORE,
- D. A. Potential causes of increased vocalisation in elderly cats with cognitive dysfunction syndrome as assessed by their owners. Animals, v.10, n.6, p.1092- 1107, 2020.
- CHAMBERS, J.K.; TOKUDA, T; UCHIDA, K.; ISHII, R.; TATEBE, H.; TAKAHASHI, E.;
- TOMIYAMA, T.; UNE, Y.; NAKAYAMA, H. The domestic cat as a natural animal model of
- Alzheimer’s disease. Acta Neuropathologica Communications, v.3, n.1, p.1-14, 2015.
- CUMMINGS, B.J.; SATOU, T.; HEAD, E.; MILGRAM, N.W.; COLE, G.M.; SAVAGE, M.J.;
- PODLISNY, M.B.; SELKOE, D.J.; SIMAN, R.; GREENBERG, B.D.; COTMAN, C.W.
- Diffuse plaques contain C-terminal Aβ42 and not Aβ40: evidence from cats and dogs.
- Neurobiology of Aging, v.17, n.4, p.653-659, 1996.
- FAST, R.; SCHÜTT, T.; TOFT, N.; MØLLER, A.; BERENDT, M. An observational study
- with long‐term follow‐up of canine cognitive dysfunction: Clinical characteristics, survival, and risk factors. Journal of Veterinary Internal Medicine, v.27, n.4, p 822-829, 2013.
- GUNN‐MOORE, D.; MOFFAT, K.; CHRISTIE, L.A.; HEAD, E. Cognitive dysfunction and
- the neurobiology of ageing in cats. Journal of Small Animal Practice, v.48, n.10, p.546-553, 2007.
- GUNN-MOORE, D.A. Cognitive dysfunction in cats: clinical assessment and management. Topics in Companion Animal Medicine, v.26, n.1, p 17-24, 2011.
- GUNN-MOORE, D.A.; MCVEE, J.; BRADSHAW, J.M.; PEARSON, G.R.; HEAD, E.;
- GUNN-MOORE, F.J. Ageing changes in cat brains demonstrated by β- amyloid and AT8-
- immunoreactive phosphorylated tau deposits. Journal of Feline Medicine & Surgery, v.8, n.4, p.234-242, 2006.
- HEAD, E.; LIU, J.; HAGEN, T.M.; MUGGENBURG, B.A.; MILGRAM, N.W.; AMES, B.N.;
- COTMAN, C. W. Oxidative damage increases with age in a canine model of human brain
- aging. Journal of Neurochemistry, v.82, n.2, p.375-381, 2002.
- HEAD, E; MOFFAT, K.; DAS, P.; SARSOZA, F.; POON, W.W.; LANDSBERG, G.;
- COTMAN, C.W.; MURPHY, M.P. β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging, v.26, n.5, p 749-763, 2005
- HEAD, E.; GUNN-MOORE, D. Neuropathology of feline dementia. In: LANDSBERG, G.
- Canine and Feline Dementia. 1. ed., Springer, Cham, 2017. p.103-111.
- KARAGIANNIS, C.; MILLS, D. Feline cognitive dysfunction syndrome. Veterinary Focus,
- v.24, n.2, p.42-7, 2014.
- KATINA, S.; FARBAKOVA, J.; MADARI, A.; NOVAK, M.; ZILKA, N. Risk factors
- forcanine cognitive dysfunction syndrome in Slovakia. Acta Veterinaria Scandinavica, v.58, n.1, p.1–7, 2016.
- LANDSBERG, G. Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v.29, n.3, p.471-479, 2005.
- LANDSBERG, G. Therapeutic options for cognitive decline in senior pets. Journal of the
- American Animal Hospital Association, v.42, n.6, p 407-413, 2006.
- LANDSBERG, G.M.; DENENBERG, S.; ARAUJO, J.A. Cognitive dysfunction in cats: a
- syndrome we used to dismiss as ‘old age’. Journal of Feline Medicine and Surgery, v.12,
- n.11, p.837-848, 2010.
- LANDSBERG, G.M.; NICHOL, J.; ARAUJO, J.A. Cognitive dysfunction syndrome: a disease
- of canine and feline brain aging. Veterinary Clinics: Small Animal Practice, v.42, n.4, p.749- 768, 2012.
- LANDSBERG, G.M.; MALAMED, R. Clinical picture of canine and feline cognitive
- impairment. In: LANDSBERG, G.M.; MALAMED, R. Canine and Feline Dementia.
- Springer, 1. ed., Editora Springer, Cham, 2017. p.1-12.
- LANDSBERG, G.M.; MADARI, A.; ŽILKA, N. Canine and Feline Dementia. 1. ed.,
- Landsberg, G., Mad’ari, A., Žilka, N., Eds, 2017. https://doi.org/10.1007/978-3-319-53219-6
- LEVINE, M.S.; ADINOLFI, A.M.; FISHER, R.S.; HULL, C.D.; BUCHWALD, N.A.;
- MCALLISTER, J.P. Quantitative morphology of medium-sized caudate spiny neurons in aged cats. Neurobiology of Aging, v.7, n.4, p.277-286, 1986.
- LEVINE, M.S.; LLOYD, R.L.; FISHER, R.S.; HULL, C.D.; BUCHWALD, N.A. Sensory,
- motor and cognitive alterations in aged cats. Neurobiology of aging, v.8, n.3, p.253-263, 1987.
- MESSONIER, S.P. Cognitive disorder (senility). The natural health bible for dogs and cats, Roseville: Prima Publishing, v.10, n.1, p.56–57, 2001.
- MIELE, A.; SORDO, L.; GUNN-MOORE, D.A. Feline aging: promoting physiologic and
- emotional well-being. Veterinary Clinics: Small Animal Practice, v.50, n.4, p.719-748, 2020.
- NEILSON, J.C.; HART, B.L.; CLIFF, K.D.; RUEHL, W.W. Prevalence of behavioral changes
- associated with age- related cognitive impairment in dogs. Journal of the American
- Veterinary Medical Association, v.218, n.11, p.1787-1791, 2001.
- PACKER, R.M.A. Cognitive dysfunction in naturally occurring canine idiopathic epilepsy.
- Plos One, v.13, n.2, p.e0192182, 2018.
- PRPAR MIHEVC, S.; MAJDIČ, G. Canine cognitive dysfunction and Alzheimer’s disease–
- two facets of the same disease? Frontiers in Neuroscience, p.604, 2019.
- https://doi.org/10.3389/fnins.2019.00604
- QUIMBY, J.; GOWLAND, S.; CARNEY, H. C.; DEPORTER, T.; PLUMMER, P.;
- WESTROPP, J. 2021 AAHA/AAFP feline life stage guidelines. Journal of the American
- Animal Hospital Association, v.57, n.2, p.51-72, 2021.
- RUEHL, W.W.; BRUYETTE, W.W.; DEPAOLI, D.S.; COTMAN, C.W.; HEAD, E.;
- MILGRAM, N.W.; CUMMINGS, B.J. Canine cognitivedysfunction as a model for human agerelated cognitivedecline, dementia, and Alzheimer’s disease: clinical presenta-tion, cognitive testing, pathology and response to l-deprenyltherapy. Program Brain Research, v.106, n.22, p.217–25, 1995.
- SÉE, V.; LOEFFLER, J.P. Oxidative stress induces neuronal death by recruiting a protease and phosphatase-gated mechanism. Journal of Biological Chemistry, v.276, n.37, p.35049-35059, 2001.
- SORDO, L. Neuropathology, diagnosis, and potential treatment of feline cognitive
- dysfunction syndrome and its similarities to Alzheimer's disease. 2021.
- https://doi.org/10.3389/fragi.2021.684607.
- SORDO, L.; GUNN‐MOORE, D.A. Cognitive dysfunction in cats: Update on
- neuropathological and behavioural changes plus clinical management. Veterinary Record, v.188, n.1, p.1-46, 2021.
- SORDO, L.; MARTINI, A.C.; HOUSTON, E.F.; HEAD, E.; GUNN-MOORE, D.
- Neuropathology of aging in cats and its similarities to human Alzheimer’s disease. Frontiers in Aging, v.2, n.106, p.18, 2021.
- TAYEBATI, S.K. Animal models of cognitive dysfunction. Mechanisms of Ageing and
- Development, v.127, n.2, p.100-108, 2006.
- TAYLOR, C. Pet health care costs rise as cats and dogs live longer than ever. Time. 2016
- Sep 13. Disponível em: http://time.com/money/4490014/pet-health-costs-rise. Acesso em: 01 abr. 2024.
- VITE, C.H.; HEAD, E. Aging in the canine and feline brain. Veterinary Clinics: Small
- Animal Practice, v.44, n.6, p 1113-1129, 2014.
- ZHANG, J.H.; SAMPOGNA, S.; MORALES, F.R.; CHASE, M.H. Age-related changes in
- cholinergic neurons in the laterodorsal and the pedunculo-pontine tegmental nuclei of cats: a combined light and electron microscopic study. Brain Research, v.1052, n.1, p.47-55, 2005. ZHANG, C.; HUA, T.; ZHU, Z.; LUO, X. Age-related changes of structures in cerebellar cortex of cat. Journal of Biosciences, v.31, n.1, p.55-60, 2006.